Evidence map›Paper›PMID 41627023›Full record

ArticleMicrobiology spectrum2026

Organ-specific immune responses are strain-dependent in a mouse model of

Man Shun Fu, Lorna George, Daisy Harris-Bosancic, Tahrim Hussain, Erin Clipston, Pui Mun Emily Chan, Lozan Sheriff, David Lecky, Kazuyoshi Kawakami, Rebecca A Drummond

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Man Shun FuInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Lorna GeorgeInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Daisy Harris-BosancicInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Tahrim HussainInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Erin ClipstonInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Pui Mun Emily ChanInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Lozan SheriffInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
David LeckyInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Kazuyoshi KawakamiDepartment of Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Rebecca A DrummondInstitute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-5424-7074

Funding

Academy of Medical Sciences SBF004_1008Lister Institute of Preventive MedicineMedical Research Council MR/S024611, MR/T029137
6 · The paper itself

Abstract

Cryptococcal meningitis remains the top cause of death from an invasive fungal infection in humans, responsible for ~100,000 deaths annually of vulnerable patients with underlying immune deficiencies. Animal models of cryptococcal meningitis are important for understanding the immune parameters that correlate with protection. However, modeling this infection in mice is challenging. There is wide variability in infection routes, doses, and mouse background used in the field, which makes understanding phenotypes of mutants and immune interventions difficult to broadly apply. Our intention was to create an observational data set for the field on how

Indexed as

BrainCryptococcosisCryptococcus neoformansMeningitis, CryptococcalAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLOrgan SpecificityCD4 T-cellcentral nervous system infectionsCryptococcus neoformansmicroglianeuroimmunologystrain variation

Identifiers

PMID41627023
PMCPMC12955457

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.