Evidence map›Paper›PMID 41627310›Full record

ArticleeLife2026

Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells.

Hiroki Tsutsumi, Tomoki Chiba, Yuta Fujii, Takahide Matsushima, Tsuyoshi Kimura, Akinori Kanai, Akio Kishida, Yutaka Suzuki, Hiroshi Asahara

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hiroki Tsutsumi *Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Tomoki Chiba *Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-5472-9030
Yuta FujiiDepartment of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Takahide MatsushimaDepartment of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Tsuyoshi KimuraLaboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Akinori KanaiLaboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Akio KishidaLaboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan.
Yutaka SuzukiLaboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Hiroshi AsaharaDepartment of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5215-8745

Funding

Mechano signals regulating tendon and ligament homeostasisR01AR080127 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI Hiroshi Asahara · 2022 to 2026
$1.9M
Japan Agency for Medical Research and Development JP21gm0810008Japan Agency for Medical Research and Development JP23ym0126805Japan Agency for Medical Research and Development JP24gm0010009Japan Agency for Medical Research and Development JP24jf0126010Japan Society for the Promotion of Science 16H06279Japan Society for the Promotion of Science JP15H02560Japan Society for the Promotion of Science JP20H05696NIAMS NIH HHS R01 AR080127NIAMS NIH HHS R01AR080127
6 · The paper itself

Abstract

Tendons and ligaments are crucial connective tissues linking bones and muscles, yet achieving full functional recovery after injury remains challenging. We investigated the characteristics of tendon stem/progenitor cells (TSPCs) by focusing on the declining tendon repair capacity with growth. Using single-cell RNA sequencing on Achilles tendon cells from 2- and 6-week-old mice, we identified

Indexed as

Achilles TendonChromatinStem CellsAnimalsCell DifferentiationMiceMice, Inbred C57BLSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisTranscription, GeneticChromatindevelopmental biologymousescRNA-seqsnATAC-seqtendon

Identifiers

PMID41627310
PMCPMC12863719

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.