Evidence map›Paper›PMID 41627464›Full record

ReviewArchives of microbiology2026

Quorum sensing in bacteria: insights into communication and inhibition strategies-a review.

Aliviya Das, Rashmita Biswas, Rudy Najiar, Pravallika Thatharaju, Sagnik Biswas, Utpal Mohan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aliviya Das *Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, 700054, India.
Rashmita Biswas *Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, 700054, India.
Rudy NajiarDepartment of Natural Products, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, 700054, India.
Pravallika ThatharajuDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, 700054, India.
Sagnik BiswasDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, 700054, India.
Utpal MohanDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, 700054, India. utpal@niperkolkata.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quorum sensing (QS) is a fundamental bacterial communication mechanism that promotes population-dependent behaviors including biofilm formation, virulence, and sporulation via signaling molecules called autoinducers. This review provides a comprehensive overview of QS and quorum sensing-mediated cross-talk in Gram-negative bacteria using N-acyl-homoserine lactones (AHLs), Gram-positive bacteria employing oligopeptides, and the universal autoinducer-2 (AI-2) system. Advances in synthetic biology and engineered QS circuits have improved understanding and control of microbial communication. The review highlights quorum quenching (QQ) and diverse classes of quorum sensing inhibitors (QSIs)-natural, synthetic, antibody-based, enzymatic, CRISPR-mediated, and those currently in clinical trials-focusing on their potential to interfere with signaling pathways and attenuate virulence. The interplay between QS, antimicrobial resistance (AMR), and QSIs is examined, emphasizing their capability to suppress pathogenicity without inducing resistance. Recent emerging approaches for QS regulation have also been mentioned. The applications of QS-targeted strategies in healthcare, agriculture, aquaculture, food industry, and medical device biofilm management are discussed, underscoring the translational promise of QSIs as sustainable, resistance-free tools for effective antimicrobial control.

Indexed as

BacteriaBacterial Physiological PhenomenaGram-Negative BacteriaQuorum SensingAcyl-ButyrolactonesAnti-Bacterial AgentsBiofilmsDrug Resistance, BacterialHomoserineSignal TransductionVirulenceAcyl-ButyrolactonesAnti-Bacterial AgentsHomoserineAntimicrobial resistanceCRISPR-mediated inhibitionQuorum sensingQuorum sensing inhibitorsSynthetic biology

Identifiers

PMID41627464

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.