Evidence map›Paper›PMID 41627465›Full record

ReviewArchives of microbiology2026

Modulating drug response through the gut microbiome: pathways to precision therapy.

Nitish Kumar, Joy Das, Murugesan Vanangamudi, Naheed Mojgani, Anas Islam, Sathvik Belagodu Sridhar, Himanshu Sharma, Sanjesh Kumar, Uttam Prasad Panigrahy, Shubhrajit Mantry and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nitish KumarSRM Modinagar College of Pharmacy, SRM Institute of Science and Technology (Deemed to be University), Delhi-NCR Campus, Modinagar, Ghaziabad, Uttar Pradesh, 201204, India.
Joy DasSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Murugesan VanangamudiInstitute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India.
Naheed MojganiRazi Vaccine and Serum Research Institute-Agricultural Research, Education and Extension organization, Karaj, 31975/148, Iran.
Anas IslamFaculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, 226026, India.
Sathvik Belagodu SridharRAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah-11172, Ras Al Khaimah, United Arab Emirates.
Himanshu SharmaDepartment of Pharmacology, Nims Institute of Pharmacy, Nims University , Jaipur, Rajasthan, 303121, India.
Sanjesh KumarDepartment of Pharmacology, School of Pharmacy, Chandigarh University, Unnao, Lucknow, Uttar Pradesh, 209859, India.
Uttam Prasad PanigrahyFaculty of Pharmaceutical Science, Assam down town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, Assam, 781026, India.
Shubhrajit MantryDepartment of Pharmacy, Sarala Birla University Birla, P.O.-Mahilong, Purulia Road, Knowledge City, Ranchi, Jharkhand, 835103, India.
Mayank SharmaSchool of Pharmacy and Technology Management, SVKM's NarseeMonjee Institute of Management Studies (NMIMS) Deemed-to- University, Mumbai, Maharashtra, 425405, India.
Mohhammad RamzanSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Priya ChaudharyCentre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai, Tamil Nadu, 603103, India. priyachaudhary@care.edu.in.ORCID http://orcid.org/0000-0001-7901-0006
Sumel AshiqueSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India. ashiquesumel007@gmail.com.ORCID http://orcid.org/0000-0003-4362-2830

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mutual association formed between the gut flora and the biological host is pivotal, mainly for drug action. Various examination has spotlighted the potential consequences of the gut microbiome on drug efficacy, revealing its role in controlling metabolism in the body. Furthermore, reciprocal engagement has been examined to investigate how pharmaceutical agents influence the composition of the gut microbiome. This paper emphasizes the intricate relationship between pharmacology and environmental microbiology, directing the extensive significance of pharmaceutical agents on health by controlling the gut microbial consortium. One main highlight of this review is to determine the differences observed in populace as a result of drugs, which is a crucial component in boosting personalized treatment approaches and intensifying therapeutic findings. Apart from their function in drug metabolization, the gut microbiota is disclosed as a source of metabolic products that can alter drug action. These microbially-derived metabolites could notably effect drug results and changes the body's physical mechanisms. The investigation suggests utilizing metabolomics to disclose the complications of gut microbiota-drug interactions. Several latest analytical strategies provide an effective tool for deciphering the complicated association among microbiome-generated fragments and pharmaceutical products, providing detailed understanding into this interesting connection.

Indexed as

Gastrointestinal MicrobiomePrecision MedicineAnimalsBacteriaHumansMetabolomicsPharmaceutical PreparationsPharmaceutical PreparationsDrug effectDrug metabolismGut microbiomePersonalized medicine

Identifiers

PMID41627465

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.