ArticleArchives of microbiology2026
The virulence regulator Rv3425 mediates stress adaptation and promotes intracellular survival of Mycobacterium tuberculosis avirulent strain.
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- PPE57 Cooperates with MmpL3 to Mediate Bacterial Lipid Transport and Promote Persistent Infection ofMicroorganisms · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Mycobacterium tuberculosis (M. tuberculosis), the etiological agent responsible for tuberculosis, possesses a gene family encoding proteins characterized by Pro-Glu/Pro-Pro-Glu motifs, collectively referred to as the PE/PPE family. Despite being a member of this family, the biological function of Rv3425, which encodes PPE57, remains poorly understood. In the current study, we investigated the role of Rv3425 in stress adaption in vitro and in the virulence of M. tuberculosis avirulent strain in cellular and murine infection models. We found that Rv3425 enhances the stress resistance of M. tuberculosis under conditions of 0.05% SDS, pH3.0 or hydrogen peroxide treatment in vitro. The knockout of rv3425 resulted in a phenotypic alteration of the mycobacterial colony morphology from the typical rough and dry appearance to an atypical smooth and moist phenotype. Further, Rv3425 localizes to the host cell nucleus, the knockout of rv3425 attenuated the survival of M. tuberculosis in THP-1 cells and in C57BL/6 mice. The transcriptional analysis identified 1370 differentially expressed genes that were enriched in cytokines production and associated signaling pathways. Notably, Rv3425 significantly suppressed the expression of IFN-α while promoting the expression of IFN-γ in infected mice. T-cell recall (IFN-γ) assay showed that Rv3425 substantially increased the antigenicity of M. tuberculosis. Altogether, we found that Rv3425 enhances survival of M. tuberculosis avirulent in macrophages and mice, and exerting immunomodulatory effects, indicating that Rv3425 is a potential target for the development of new diagnostic techniques or therapeutic strategies against tuberculosis.
Indexed as
Identifiers
41627469What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.