ArticleMolecular biology reports2026
Frequency of CIT, EBC and DHA flocks (families) of AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae collected from hospitalized patients in North of Iran.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundKlebsiella pneumoniae exhibits a marked propensity for acquiring beta-lactam resistance genes. Among these, AmpC beta-lactamases are able to hydrolyze a broad spectrum of antibiotics including first- through third-generation cephalosporins, cephamycins, and aztreonam. The CIT, EBC, and DHA families are among the most clinically significant plasmid-mediated AmpC variants in this pathogen. Consequently, this study aimed to investigate the prevalence of genes encoding these specific enzymes among clinical isolates of K. pneumoniae in northern Iran.
methodsOne hundred clinical isolates were collected from hospitalized patients and identified using standard microbiological and biochemical assays. The antimicrobial resistance profile of each isolate was determined via the disk agar diffusion method. Subsequently, PCR test was employed to detect the presence of the bla
resultsThe mean age of the patients (58 females and 42 males) was 50.31 years. Isolates were sourced from patients in general (41%), pediatric (45%), burn (7%), and infectious (7%) hospitals. The primary specimen sources were urine (64%), blood (10%), tissue (15%), wound (7%), and sputum (4%). The highest prevalence of resistance (93%) was observed against ampicillin-sulbactam, whereas 73% of isolates remained susceptible to ertapenem.
conclusionThe high ampicillin-sulbactam resistance represents a serious concern for the management of hospital-acquired infections. Furthermore, while the presence of the investigated bla
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