Evidence map›Paper›PMID 41628837›Full record

ArticleNeurotoxicology2026

The long-acting anticoagulant rodenticide brodifacoum induces neuropathology in adult New Zealand White rabbits and is reduced by the bile sequestrant cholestyramine.

Intakhar Ahmad, Jacqueline Rocha, Zachary McDonald, Douglas L Feinstein

Abstract read
In one paragraph

Article in Neurotoxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Intakhar AhmadDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL 60612, USA; Research & Development Service, Jesse Brown VA Medical Center, Chicago, IL 60612, USA.
Jacqueline RochaDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Zachary McDonaldDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Douglas L FeinsteinDepartment of Anesthesiology, University of Illinois College of Medicine, Chicago, IL 60612, USA; Research & Development Service, Jesse Brown VA Medical Center, Chicago, IL 60612, USA. Electronic address: dlfeins@uic.edu.

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RANDY STRONG, Adam Salmon · 1995 to 2026
$30.6M
San Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Elena Volpi · 2015 to 2026
$14.1M
Optimization of Bile Sequestrants to Treat Superwarfarin PoisoningU01NS127746 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Douglas L. Feinstein · 2022 to 2026
$3.3M
NIA NIH HHS P30 AG013319NIA NIH HHS P30 AG044271NINDS NIH HHS U01 NS127746
6 · The paper itself

Abstract

Previous studies showed that exposure to long-acting anticoagulant rodenticides (LAARs) can induce neuropathology in adult rats. In the current study we tested if the potent LAAR brodifacoum similarly promoted neuropathology in adult rabbits which provide a better model of human LAAR poisoning. Adult male New Zealand White rabbits were administered by gavage a single administration of brodifacoum at its LD

Indexed as

4-HydroxycoumarinsAnticoagulantsCerebellumCholestyramine ResinRodenticidesAnimalsMaleRabbits4-HydroxycoumarinsAnticoagulantsbromfenacoumCholestyramine ResinRodenticidesAnti-coagulantBrodifacoumCholestyramineGlial cellsMyelin

Identifiers

PMID41628837
PMCPMC13355867

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.