Evidence map›Paper›PMID 41629155›Full record

ArticleJournal of medicinal chemistry2026

Discovery of Spiro[chromane-2,4'-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV-2 Papain-like Protease.

Qiangqiang Wei, Ashley J Taylor, Nagaraju Miriyala, Mahesh A Barmade, Zachary O Gentry, Jordan Anderson-Daniels, Kevin B Teuscher, Mackenzie M Crow, Chideraa Apakama, Taylor M South and 7 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Qiangqiang WeiDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Ashley J TaylorDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0002-0568-7652
Nagaraju MiriyalaDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0002-1265-738X
Mahesh A BarmadeDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0002-8685-7333
Zachary O GentryDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0002-0418-6063
Jordan Anderson-DanielsDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Kevin B TeuscherDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0009-0008-1039-015X
Mackenzie M CrowDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Chideraa ApakamaDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Taylor M SouthDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Tyson A RietzDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0003-4670-5279
Kangsa AmporndanaiDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0001-8527-9394
Jason PhanDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
John L SensintaffarDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Mark DenisonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Taekyu LeeDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Stephen W FesikDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0001-5957-6192

Funding

Automated Compound Storage and Retrieval SystemS10OD028715 · OD · VANDERBILT UNIVERSITY · PI BAUER, JOSHUA A. · 2022 to 2022
$741k
NIH HHS S10 OD028715
6 · The paper itself

Abstract

The papain-like protease (PL

Indexed as

Antiviral AgentsPiperidinesProtease InhibitorsSARS-CoV-2Spiro CompoundsCoronavirus Papain-Like ProteasesCrystallography, X-RayDrug DiscoveryHumansMolecular Dynamics SimulationStructure-Activity RelationshipAntiviral AgentsCoronavirus Papain-Like Proteasespapain-like protease, SARS-CoV-2PiperidinesProtease InhibitorsSpiro Compounds

Identifiers

PMID41629155
PMCPMC12910659

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.