Evidence map›Paper›PMID 41629364›Full record

ArticleNPJ genomic medicine2026

Linking the microbiome to the complement system in geographic atrophy.

Livia Spörri, Justyna M Studer, Marco Kreuzer, Jérémy Rotzetter, Daniel Schärer, Carlo R Largiadèr, Damian Jaggi, Martin S Zinkernagel, Denise C Zysset-Burri

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ genomic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02438111 unknown statusnot on this map

The Role of the Gut Metagenome on the Development of Age Related Macular Degeneration (AMD)

TypeobservationalSponsorInsel Gruppe AG, University Hospital BernRan2013 to 2023Enrolled1,200ConditionsAge Related Macular DegenerationArmsmetagenome
NCT04658238 recruitingnot on this map

Associations of the Ocular Microbiome and the Immune System in Dry Eye Disease

TypeobservationalSponsorInsel Gruppe AG, University Hospital BernRan2020 to 2026Enrolled600ConditionsDry Eye DiseaseArmsOcular microbiome, Ocular immune system
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Livia Spörri *Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Justyna M Studer *Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marco KreuzerInterfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern, Switzerland.
Jérémy RotzetterDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Daniel SchärerDepartment of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Carlo R LargiadèrDepartment of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Damian JaggiDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Martin S ZinkernagelDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Denise C Zysset-BurriDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. denise.zysset@insel.ch.

Funding

Foundation Bertarelli Catalyst Fund, EPFL (Ecole Polytechnique Fédérale de Lausanne), Lausanne, Switzerland CF10000044-EPFL SCR0237812
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause of vision loss in the aged population with the late stage geographic atrophy (GA). Risk factors for AMD include age, genetic variants in the complement system, nutritional factors, and alterations in the gut microbiome (GM). To identify taxonomic and functional differences in the microbiome associated to disease pathophysiology and genetic risk factors, this study investigated the GM and the ocular surface microbiome (OSM) of GA patients compared to healthy controls by whole-metagenome shotgun sequencing. 16 AMD-associated SNPs were genotyped from blood samples using TaqMan assays and Sanger sequencing. While GA patients showed differences in the GM, and altered metabolic pathways including inosine 5'-phosphate degradation, NAD salvage, and ketogenesis, no alterations in the OSM were found. Genetic analysis associated SNP rs1061170 in the complement factor H gene with GA. These findings suggest that microbial alterations may contribute to GA through inflammation and oxidative stress.Registry: ClinicalTrials.gov, NCT02438111, Registration date: 28 April 2015, and NCT04658238, Registration date: 01 December 2020.

Identifiers

PMID41629364
PMCPMC12963446

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.