Evidence map›Paper›PMID 41629503›Full record

ArticleEndocrine2026

A pilot study on measured insulin sensitivity and estimated glucose disposal rates in adults with type 1 diabetes and diabetic kidney disease.

Johan R Simonsen, Daniel Gordin, Andrzej S Januszewski, Alicia J Jenkins, Daniël H van Raalte, Michael Jb van Baar, Petter Bjornstad, Lena M Thorn, Per-Henrik Groop

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Article in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Johan R SimonsenFolkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.
Daniel GordinDepartment of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Andrzej S JanuszewskiSydney Pharmacy School, University of Sydney, Sydney, Australia.
Alicia J JenkinsNHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.
Daniël H van RaalteDiabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VU University Medical Center, Amsterdam, The Netherlands.
Michael Jb van BaarDiabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, location VU University Medical Center, Amsterdam, The Netherlands.
Petter BjornstadDepartment of Medicine, Division of Metabolism, Endocrinology, and Nutrition, Seattle Children's Research Institute, University of Washington Medicine Diabetes Institute (UWMDI), University of Washington School of Medicine, Washington, United States of America.
Lena M ThornFolkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland. lena.thorn@helsinki.fi.
Per-Henrik GroopFolkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDiabetic kidney disease (DKD) in type 1 diabetes has been shown to be strongly associated with insulin resistance, but this has not been previously explored using the euglycemic-hyperinsulinemic clamp. Therefore, we investigated insulin sensitivity in people with type 1 diabetes with and without DKD using M/I-values (mean glucose disposal rates [GDR]/mean plasma insulin) and compared GDRs to estimated GDR (eGDR)-formulae.

methodsIn this pilot study, we studied 17 adult individuals with type 1 diabetes (ten with and seven without DKD) using euglycemic-hyperinsulinemic clamps and assessed correlations between GDR and eGDR values.

resultsM/I-values were 62.5% lower in individuals with type 1 diabetes and DKD compared to those without DKD, albeit not statistically significant (0.16 ± 0.08 vs. 0.10 ± 0.08 mg/kg/min per mIU/L, P = 0.154). In the whole group (n = 17) eGDR by Williams et al. demonstrated the highest correlation with GDR (r = 0.35, P = 0.167), while eGDR by Januszewski et al. had the highest correlation in the DKD group (n = 10, r = 0.46, P = 0.177).

conclusionOur pilot study suggests the possibility of increased insulin resistance in people with type 1 diabetes and DKD.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 1Diabetic NephropathiesInsulin ResistanceAdultFemaleGlucose Clamp TechniqueHumansInsulinMaleMiddle AgedPilot ProjectsBlood GlucoseInsulinDiabetic complications.Diabetic kidney diseaseInsulin sensitivityType 1 diabetes

Identifiers

PMID41629503
PMCPMC12864270

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.