Evidence map›Paper›PMID 41629610›Full record

Reviewnpj metabolic health and disease2026

Sepsis and the immunometabolic inflammatory response.

Samuel N Paul, Isabell Nessel, Zudin Puthucheary, Siân M Henson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in npj metabolic health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel N PaulCentre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Isabell NesselCentre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Zudin PuthuchearyCentre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Siân M HensonCentre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK. s.henson@qmul.ac.uk.

Funding

Barts Charity G-002143Biotechnology and Biological Sciences Research Council BBX009610
6 · The paper itself

Abstract

Sepsis is a life-threatening syndrome characterised by dysregulated immunity, inflammation and metabolic disruption. Despite improved care, it remains a major cause of morbidity and mortality, highlighting the need for improved mechanistic insight. Immunometabolism has emerged as a framework for understanding sepsis pathophysiology. Conventional prognostic tools reflect downstream organ injury but not the metabolic states of immune cells. Emerging technologies now enable high-resolution profiling of immunometabolic changes and integrating these approaches may yield metabolic biomarkers capable of tracking immune function and refining diagnostics. This review summarises current knowledge of leukocyte metabolic dysfunction in sepsis and highlights how immunometabolic profiling can inform patient monitoring and advance biomarker-driven precision medicine.

Identifiers

PMID41629610
PMCPMC12865009

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.