ReviewMedical science monitor : international medical journal of experimental and clinical research2026
Neuroimmune Mechanisms and Emerging Intervention Strategies for Post-Stroke Fatigue: A Narrative Review.
Review in Medical science monitor : international medical journal of experimental and clinical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-stroke fatigue is a prevalent sequela of stroke that substantially impairs patients' quality of life and rehabilitation progress, yet its mechanisms and management remain heterogeneous. This narrative review synthesizes current evidence on neuroimmune pathways implicated in post-stroke fatigue and appraises emerging mechanism-targeted interventions. Studies published between 2003 and 2025 were included; all were sourced from PubMed, Web of Science, or Scopus. Search terms included "post-stroke fatigue", "neuroinflammation", "pharmacological interventions", "neuromodulation", and related terms. Only full-text, English-language articles were considered; studies were selected according to their focus on post-stroke fatigue mechanisms or interventions. Convergent data implicate low-grade, cytokine-mediated inflammation; dysregulation of the monoaminergic system - particularly dopamine and serotonin; and hyperactivity of the hypothalamic-pituitary-adrenal axis. Interventions aligned with these pathways show promise, including immunomodulation with interleukin-1 receptor antagonists; neuromodulation with transcranial direct current stimulation and repetitive transcranial magnetic stimulation; pharmacotherapy with selective serotonin reuptake inhibitors or modafinil; and non-pharmacological strategies such as aerobic exercise and cognitive behavioral therapy. A neuroimmune-informed, mechanism-targeted approach may improve outcomes in post-stroke fatigue. Priorities include standardized definitions, harmonized outcome measures, and adequately powered trials to confirm effectiveness across phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.