Evidence map›Paper›PMID 41630761›Full record

ArticleOpen veterinary journal2025

I Gede Widhiantara, Putu Angga Wiradana, Anak Agung Ayu Putri Permatasari, Ni Kadek Yunita Sari, I Made Gde Sudyadnyana Sandhika, Novaria Sari Dewi Panjaitan, Mochammad Aqilah Herdiansyah, Intan Ayu Pratiwi

Abstract read
In one paragraph

Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

I Gede WidhiantaraStudy Program of Biology, Faculty of Health and Science, Universitas Dhyana Pura, Bali, Indonesia.
Putu Angga WiradanaStudy Program of Biology, Faculty of Health and Science, Universitas Dhyana Pura, Bali, Indonesia.
Anak Agung Ayu Putri PermatasariStudy Program of Biology, Faculty of Health and Science, Universitas Dhyana Pura, Bali, Indonesia.
Ni Kadek Yunita SariStudy Program of Biology, Faculty of Health and Science, Universitas Dhyana Pura, Bali, Indonesia.
I Made Gde Sudyadnyana SandhikaStudy Program of Biology, Faculty of Health and Science, Universitas Dhyana Pura, Bali, Indonesia.
Novaria Sari Dewi PanjaitanCenter for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Bogor, Indonesia.
Mochammad Aqilah HerdiansyahDepartment of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Intan Ayu PratiwiDepartment of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.

Funding

Institute for Research and Community Service (LPPM) at Universitas Dhyana Pura (UNDHIRA-BALI)
6 · The paper itself

Abstract

Background: Atherosclerosis is often associated with inflammation and non-alcoholic liver disease due to high-cholesterol diet and the side effects of conventional treatment. Aim: This study aimed to determine the efficacy of Methods: Hypercholesterolemia induction was achieved by oral administration of feed with lard for 21 days in male Wistar rats. Next, the animals were treated with 4 mg/kg BW of BBLE (single dose) and 4 mg/kg BW of BBLE+SAE (combined dose) for 3 months, and continued to be given a high cholesterol diet. The negative control was a high cholesterol diet, and the positive control was simvastatin. Blood samples were taken to determine total cholesterol, apolipoprotein-E (Apo-E), interleukin-6, tumor necrosis factor-α, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels. Meanwhile, the weight of the liver and histopathology preparations were weighed. Results: Giving BBLE+SAE was able to reduce body weight, liver weight, and cholesterol levels significantly compared to negative controls ( Conclusion: Administration of BBLE+SAE acts as an anti-atherosclerotic and hepatoprotective agent for the liver through reducing pro-inflammatory cytokines, and its use was promising for clinical studies.

Indexed as

Anti-Inflammatory AgentsAtherosclerosisHypercholesterolemiaPlant ExtractsProtective AgentsSargassumAnimalsCholesterolCholesterol, DietaryLiverMaleRatsRats, WistarAnti-Inflammatory AgentsCholesterolCholesterol, DietaryPlant ExtractsProtective AgentsAnti-inflammationAtherosclerosisHepatoprotectiveHerbal medicineSub-chronic toxicity

Identifiers

PMID41630761
PMCPMC12861430

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.