ArticleOsteoarthritis and cartilage open2026
The stability of pain phenotypes in people with hand osteoarthritis - results from the NOR-HAND study.
Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Osteoarthritis phenotypes: advancing precision medicine through clinical, structural, and molecular stratification.International orthopaedics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: In a hand osteoarthritis (OA) cohort, we aimed to explore pain phenotypes and characterize their stabilities using the multidimensional framework developed by The Initiative on Methods, Measurement and Pain Assessment in Clinical Trials (IMMPACT). Methods: We included participants attending the visits at baseline (2016-17) and follow-up (2019-21) in the Nor-Hand study. To identify pain phenotypes (i.e., classes), we conducted latent transition analyses modelling self-reported pain severity, neuropathic-like pain, fatigue, sleep, anxiodepressive symptoms, pain catastrophizing, and quantitative sensory testing (QST). We compared a model including QST with a model without. Longitudinal stability of classes was assessed. Changes in indicator variables across participants with vs. without between-class transitioning were compared. Results: We analysed 213 participants (86.9 % women) with a baseline mean age (standard deviation) of 60.9 (6.0) years. Both models identified four classes exhibiting similar results on differences in pain severity and psychosocial burden (kappa 0.91). Although phenotype stability varied (probability range: 0.48-0.95), most participants ( Conclusion: Four distinct pain phenotypes were identified among persons with hand OA. Excluding QST from our model did not influence phenotype composition or characteristics. Various longitudinal phenotype stability was observed. Between-class transitions were often characterized by less pain and psychosocial burden, potentially due to regression to the mean or improved disease coping.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.