Evidence map›Paper›PMID 41630896›Full record

ArticleKidney international reports2026

Home-Based Exercise Improves Muscle Oxidative Capacity in Kidney Disease.

Gwénaëlle Begue, Armin Ahmadi, Christopher Mt Hayden, Alec Foster, Usman Rehman, Jennifer E Norman, Chenoa Vargas, Brian J Bennett, Craig McDonald, T Alp Ikizler and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gwénaëlle BegueKinesiology Department, California State University, Sacramento, California, USA.
Armin AhmadiDepartment of Medicine, Division of Nephrology, University of California Davis, Sacramento, California, USA.
Christopher Mt HaydenDepartment of Neurobiology, Physiology, and Behavior, University of California Davis, Davis, California, USA.
Alec FosterKinesiology Department, California State University, Sacramento, California, USA.
Usman RehmanDepartment of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.
Jennifer E NormanDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, Davis, California, USA.
Chenoa VargasDepartment of Medicine, Division of Nephrology, University of California Davis, Sacramento, California, USA.
Brian J BennettDepartment of Nutrition, University of California Davis, California, USA.
Craig McDonaldDepartments of Physical Medicine and Rehabilitation and Pediatrics, Lawrence J. Ellison Ambulatory Care Center, University of California Davis Health, Sacramento, California, USA.
T Alp IkizlerDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University, Nashville, Tennessee, USA.
Hiba HamdanDepartment of Medicine, Division of Nephrology, University of California Davis, Sacramento, California, USA.
Lucas SmithDepartment of Neurobiology, Physiology, and Behavior, University of California Davis, Davis, California, USA.
Tae Youn KimBetty Irene Moore School of Nursing, University of California Davis, Sacramento, California, USA.
Thomas JueDepartment of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.
Jorge GamboaDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Baback RoshanravanDepartment of Medicine, Division of Nephrology, University of California Davis, Sacramento, California, USA.

Funding

The Training Core for The San Diego Regional Network Award for Kidney, Urologic, and Hematologic Research TrainingTL1DK143272 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$404k
NIDDK NIH HHS TL1 DK143272
6 · The paper itself

Abstract

Introduction: Muscle impairment in chronic kidney disease (CKD) contributes to decreased physical performance, frailty, and increased mortality. This proof-of-concept randomized controlled study evaluated the efficacy of a 12-week home-based, video-supervised exercise program on muscle endurance in moderate-to-severe nondialysis CKD. Methods: Thirty-two sedentary adults with CKD (estimated glomerular filtration rate [eGFR] < 60 ml/min per 1.73 m Results: Mean (SD) ages were 62.6 (10.8) years in EX and 67.2 (8.2) in UC. Mean eGFRs were 35.0 (12.6) and 32.3 (12.0) ml/min per 1.73 m Conclusion: Home-based, video-supervised exercise is feasible, improves muscle oxidative capacity and endurance, offering a strategy to mitigate functional decline in moderate-to-severe nondialysis CKD.

Indexed as

chronic kidney diseaseexercisein-vivo mitochondrial bioenergeticsmagnetic resonance spectroscopymuscle oxidative capacityphysical performance

Identifiers

PMID41630896
PMCPMC12861209

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.