ReviewiScience2026
Maternal environmental exposure and early-life health risks: The modulating role of nutritional status-A scoping review.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidence suggests that maternal food intake and nutritional status may modify the relationship between environmental toxicants and early-life health risks, potentially mitigating their adverse effects. However, the interplay between nutritional status, environmental exposures, and health outcomes remains poorly characterized in the literature. Notably, foods can serve as the dual source of toxins (e.g., methylmercury in fish) and protective nutrients (e.g., omega-3 fatty acids), which complicate their role in risk reduction. This scoping review aims to evaluate the extent of research on how maternal nutrition (from both dietary intake and supplements) modify the risk of adverse early-life outcomes associated with environmental exposures. We also identified critical research gaps to guide future investigations. Our search included identified English-language, free full-text articles from PubMed and Google Scholar published up to November 2025. Among the 60 included studies (55 observational and 5 interventional), most were conducted in the USA (42%), with toxic metals (33%) and endocrine disrupting chemicals (EDCs) (20%) as the primary exposures. Folate (28%) and fish/fatty acids (15%) were the most frequently studied nutrients/food sources. Neurodevelopmental/behavioral disorders (42%) and adverse birth outcomes (32%) were the predominant endpoints. Maternal nutrition, particularly folate, fish, vitamins, and minerals, may mitigate environmental exposure-related risks. The findings suggest that folate may modify health risks from air pollution, toxic metals, and smoking, whereas fish intake, fatty acids, selenium, and vitamins A, B, C, D, and E may modify the effects of air pollution, EDCs, toxic metals, and smoking. Future research should prioritize mechanistic studies, optimal dosages, and longitudinal designs in diverse populations.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.