Evidence map›Paper›PMID 41631127›Full record

ReviewJournal of pathology informatics2026

Applications and challenges of utilizing digital pathology and AI-enabled workflows in clinical trials.

Manu Sebastian, Harsh Batra, Monika Lamba Saini, Staci Kearney, Lorcan Sherry, Serge Alexanian, Michael Cohen, William Weber, Joe Lennerz, Anil V Parwani

Erratum issuedAbstract readReview
In one paragraph

Review in Journal of pathology informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Manu SebastianThe University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America.
Harsh BatraMcMaster University, Hamilton L8S 4L8, Canada.
Monika Lamba SainiADC Therapeutics, Imperial College, White City Campus, London W12 0BZ, UK.
Staci KearneyElevation Strategic Development, 7314 Rossman Gulch Rd, Morrison, CO 8046, United States of America.
Lorcan SherryOracleBio Limited, Biocity Scotland, North Lanarkshire ML1 5UH, UK.
Serge AlexanianPictor Labs, Los Angeles, CA 90064, United States of America.
Michael CohenWake Forest University School of Medicine, Bowman Gray Center for Medical Education, 475 Vine Street, Winston-Salem, NC 27101, United States of America.
William WeberTakeda, 650 E Kendall St, Cambridge, MA 02142, United States of America.
Joe LennerzBostonGene, University Office Park III, 95 Sawyer Road, Waltham, MA 02453, United States of America.
Anil V ParwaniWexner Medical Center, Ohio State University, 410 W 10th Ave, Columbus, OH 43210, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This is a comprehensive review on current utilization and challenges of digital pathology adoption in clinical trials and aims to provide a broad view on its impact on pathology review processes in clinical trials. It provides an overview of current pathology review practices in clinical trials and unique advantages digital pathology adoption can offer. The key areas including existing workflows, use case scenarios in different disease areas in clinical trials, including but not limited to patient identification and pre-screening, and regulatory aspects have been described with relevance. In addition, the review delves into the integration of genomics, AI, image analysis, radiology, and advanced computational pathology, to propose measures to enhance clinical trial outcomes. The current regulatory landscape around digital pathology adoption and potential future advancements in this field are also discussed as appropriate.

Indexed as

Artificial intelligenceClinical trialsDigital pathologyPrecision medicineRegulationsTranslational medicine

Identifiers

PMID41631127
PMCPMC12861029

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.