Evidence map›Paper›PMID 41631925›Full record

ArticleThe Journal of physiology2026

Role of Septin7 in mitochondrial dynamics and oxidative metabolism in C2C12 skeletal muscle cells.

Andrea Telek, Ivett Gabriella Szabó, Anikó Keller-Pintér, Mónika Gönczi, Eliza Guti, László Szabó, Brigitta Tillmann, Zoltán Márton Kohler, László Juhász, Péter Bai and 4 more

Abstract read
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In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrea TelekDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Ivett Gabriella SzabóDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Anikó Keller-PintérDepartment of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Mónika GöncziDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Eliza GutiDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
László SzabóDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Brigitta TillmannDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Zoltán Márton KohlerDepartment of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
László JuhászInstitute of Surgical Research, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Péter BaiDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Szilárd PóliskaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Zsuzsanna GaálInstitute of Pediatrics, University of Debrecen, Debrecen, Hungary.
László CsernochDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
János FodorDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.ORCID 0000-0002-3702-2903

Funding

HUN-REN Hungarian Research Network K142141Incubation Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation of the University of SzegedMinistry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund TKP2021-NKTAMinistry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund TKP2021-NKTA-34Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund TKP2021-EGANational Research, Development and Innovation Office NKFI OTKA K 137600National Research, Development and Innovation Office of Hungary NKFI FK 134684
6 · The paper itself

Abstract

Mitochondria are dynamic organelles that undergo fusion and fission. Key proteins are needed to create mitochondrial networks, as well as facilitate biogenesis, fragmentation or movement within the cell. Septins are considered as the fourth component of the cytoskeleton, providing attachment sites for proteins. Besides that, they have important roles in different cellular processes, including mitochondrial fission and fusion (remodelling). Septins form oligomeric complexes comprising various septin subgroups, which can create higher-order structures. Septin7 is the sole member of its subgroup. We aimed to examine how mitochondrial dynamics and oxidative phosphorylation (OXPHOS) are affected in Septin7 downregulated C2C12 (S7-KD) myoblasts and terminally differentiated myotubes compared to scrambled short hairpin RNA-transfected control cells. We detected altered expression of genes related to mitochondrial biogenesis (PGC1α), dynamics (DRP1, OPA1 and MFN2) and autophagy (PINK1 and BNIP3); furthermore, a significant decrease in differentiation-dependent mRNA expression of OXPHOS markers (ATP synthase, COX1 and SDH). Septin7 downregulation also affected the expression of post-translational modifications of MFN2 and DRP1. Functional measurements of OXPHOS revealed decreased O

Indexed as

Mitochondrial DynamicsMuscle Fibers, SkeletalMuscle, SkeletalOxidative PhosphorylationSeptinsAnimalsCell LineMiceMyoblastsSept7 protein, mouseSeptinselectron transportmitochondriaremodellingseptinskeletal muscle

Identifiers

PMID41631925
PMCPMC12953023

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.