Evidence map›Paper›PMID 41633586›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026

[Effects of cold atmosphere plasma treatment on the biological behavior of human gingival fibroblasts].

M Zheng, X Ma, H Chen, H Zhao, Y Zhang, J Tan, H Li, X Wang

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M ZhengDepartment of Stomatology, Peking University Third Hospital, Beijing 100191, China.
X MaDepartment of Stomatology, Peking University Third Hospital, Beijing 100191, China.
H ChenSchool of Clinical Medicine, Tsinghua University (Beijing Tsinghua Changgung Hospital), Beijing 100084, China.
H ZhaoDepartment of Engineering Physics, Tsinghua University, Beijing 100084, China.
Y ZhangSchool of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
J TanDepartment of Prosthodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
H LiDepartment of Engineering Physics, Tsinghua University, Beijing 100084, China.
X WangDepartment of Stomatology, Peking University Third Hospital, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo preliminarily investigate the effects of direct treatment with cold atmosphere plasma (CAP) on the migration and proliferation capabilities of human gingival fibroblasts (HGFs), as well as the correlation between the doses and the effects.

methodsThe CAP Bio-Med Platform was used to generate the CAP in this study. The characteristics of the CAP source were kept constant by fixing the discharge voltage, frequency, and gas flow rate. Different CAP doses were generated by adjusting the discharge time (20 s, 60 s, 120 s, 180 s) and used to treat HGFs. The temperature, pH, and reactive oxygen species (ROS) levels in the HGFs culture medium were measured following treatment with different CAP doses. The morphology of the HGFs after treatment was observed

resultsAs the treatment duration increased, the CAP dose generated by the platform ranged from 0 J to 210.6 J. Different CAP doses did not affect the temperature of the HGFs culture medium. As the CAP dose increased, the pH of the HGFs culture medium first decreased from an initial 8.18±0.06 to 8.13±0.20, then gradually increased to 8.63±0.15 (

conclusionTreatment with different doses of CAP alters the pH and ROS levels of the HGFs culture medium. CAP treatment has a dose-dependent effect on the biological behavior of HGFs: Low-dose treatment enhances migration and proliferation, while excessively high-dose treatment inhibits these abilities.

Indexed as

Cell MovementCell ProliferationFibroblastsGingivaPlasma GasesCells, CulturedCold TemperatureHumansReactive Oxygen SpeciesPlasma GasesReactive Oxygen SpeciesCold atmospheric plasmaFibroblastsGingivaReactive oxygen species

Identifiers

PMID41633586
PMCPMC12872359

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.