ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026
[Total Astragalus saponins reduce astrocyte swelling and AQP4 expression following oxygen-glucose deprivation and reoxygenation by inhibiting the p38 pathway].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the effect of total Astragalus saponins (AST) on astrocyte swelling induced by glucose-oxygen deprivation and reoxygenation (OGD/R) and its molecular mechanism.
methodsPrimary astrocytes isolated from the brain of post-natal day 2 SD rats were treated with solvent vehicle, AST, or AST combined with U-46619 (a p38 activator) 24 h prior to and during exposure to OGD/R. The changes in cell volume and morphology were observed, and intracellular reactive oxygen species (ROS) levels and lactate dehydrogenase (LDH) activity were detected. The expression of aquaporin 4 (AQP4) on cell membrane was observed using immunofluorescence confocal microscopy, and Western blotting was performed to detect the changes in p38 signaling pathway phosphorylation levels and AQP4 expression level.
resultsAST treatment significantly reduced OGD/R-induced increase in astrocyte volume, ROS levels and LDH release. The AST-treated cells also exhibited improved cell morphology, reduced aggregation of AQP4 on the cell membrane, and decreased p38 phosphorylation and AQP4 expression levels. The protective effects of AST against OGD/R-induced cell injuries were significantly attenuated by combined treatment of the cells with U-46619.
conclusionsAST alleviate astrocyte swelling induced by OGD/R injury by inhibiting the activation of the p38 signaling pathway and AQP4 overexpression on the cell membrane.
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