Evidence map›Paper›PMID 41633690›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

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Binjie Li, Xiaofang Zhou, Xiaomeng Lang, Xin Kang, Jianping Liu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Binjie LiGraduate School, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Xiaofang ZhouDepartment of Integrated Traditional Chinese and Western Medicine, China People's Police University Hospital, Langfang 065000, China.
Xiaomeng LangDepartment of Spleen and Stomach Diseases, First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China.
Xin KangDepartment of Spleen and Stomach Diseases, First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China.
Jianping LiuDepartment of Spleen and Stomach Diseases, First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the mechanism of

methodsSD rat models of UC were randomized into 5 groups (

resultsThe rat models of UC showed obvious colonic mucosal damage with massive inflammatory cell infiltration, increased IL-6 and IL-17 levels and lowered IL-10 level in both the serum and colonic tissues, reduced expression levels of occludin and ZO-1, increased Th17 and lowered Treg cell percentages, increased RORγt mRNA and protein expressions, and reduced Foxp3 mRNA and protein expressions in the colonic tissue. Treatment with XZJD significantly alleviated inflammatory response in the colonic mucosa and effectively reversed the changes in IL-6, IL-17 and IL-10 levels, expressions of occludin and ZO-1, percentages of Th17 and Treg cells, and the expressions of RORγt and Foxp3 in the colonic tissues of UC rats.

conclusionsXZJD can alleviate pathologies in the colonic mucosa in UC rats possibly by regulating Th17/Treg immune balance.

Indexed as

Colitis, UlcerativeDrugs, Chinese HerbalTh17 CellsT-Lymphocytes, RegulatoryAnimalsColonForkhead Transcription FactorsInterleukin-10Interleukin-17Interleukin-6MaleNuclear Receptor Subfamily 1, Group F, Member 3OccludinRatsRats, Sprague-DawleyZonula Occludens-1 ProteinDrugs, Chinese HerbalForkhead Transcription FactorsFoxp3 protein, ratInterleukin-10Interleukin-17Interleukin-6Nuclear Receptor Subfamily 1, Group F, Member 3OccludinTjp1 protein, ratZonula Occludens-1 Proteinintestinal barrierTh17/Treg immune balanceulcerative colitisXiezhuo Jiedu Recipe

Identifiers

PMID41633690
PMCPMC12867630

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.