ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026
[Cajanonic acid A derivative XJ-60 improves liver fibrosis in mice with non-alcoholic fatty liver disease by inhibiting the SP1/TGF-β/Smad3 signaling axis].
Zhaodie Geng, Li Hu, Yunli Dai, Ronggang Luo, Tao Xu, Xuyang Liao, Zhiping Yuan, Jianta Wang, Ying Xiao
Abstract readEnglish Abstract
In one paragraphArticle in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Zhaodie GengGuizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases//Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, China.
Li HuGuizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases//Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, China.
Yunli DaiGuizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases//Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, China.
Ronggang LuoGuizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases//Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, China.
Tao XuGuizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases//Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, China.
Xuyang LiaoGuizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases//Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, China.
Zhiping YuanHospital of Guizhou Medical University, Guiyang 550025, China.
Jianta WangGuizhou Provincial Engineering Research Center for Chemical Drug Development and Utilization, Guiyang 550004, China.
Ying XiaoGuizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases//Department of Pathophysiology, Guizhou Medical University, Guiyang 550025, China.
Funding
National Natural Science Foundation of China 82360149
6 · The paper itselfAbstract
objectivesTo investigate the mechanism of XJ-60, a derivative of cajanonic acid A, for alleviating liver fibrosis in mice with non-alcoholic fatty liver disease (NAFLD).
methodsTwelve
resultsXJ-60 treatment significantly reduced serum lipid levels, improved liver histology, and lowered hepatic IL-6 expression in
conclusionsXJ-60 ameliorates liver fibrosis and steatosis in mice with NAFLD possibly through SP1-mediated inhibition of the TGF‑β/Smad3 pathway to reduce ECM deposition.
Indexed as
Liver CirrhosisNon-alcoholic Fatty Liver DiseaseAnimalsIsoquinolinesMaleMiceMice, Inbred C57BLPyridinesPyrrolesSignal TransductionSmad3 ProteinSp1 Transcription FactorStilbenesTransforming Growth Factor beta6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloridecajanonic acid AIsoquinolinesPyridinesPyrrolesSmad3 ProteinSmad3 protein, mouseSp1 Transcription FactorStilbenesTransforming Growth Factor betacajanonic acid A derivativenon-alcoholic fatty liver diseaseSmad3 proteinspecific protein 1transforming growth factor‑β
Identifiers
PMID41633693
PMCPMC12867612
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