Evidence map›Paper›PMID 41633696›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[High expression of MPP6 predicts poor patient prognosis and promotes malignant biological behaviors of hepatocellular carcinoma cells].

Huihao Yu, Yu Shao, Qianqian Cheng, Xinrui Zhou, Haiping Geng, Yan Yang

Abstract readEnglish Abstract
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Huihao YuDepartment of Medical Oncology, First Afiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Yu ShaoClinical Trial Research Center, First Afiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Qianqian ChengDepartment of Gastroenterology, First Afiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Xinrui ZhouDepartment of Medical Oncology, First Afiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Haiping GengDepartment of Medical Oncology, First Afiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Yan YangDepartment of Medical Oncology, First Afiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the expression of membrane protein palmitoylated 6 (MPP6) in hepatocellular carcinoma (HCC) and analyze its correlation with clinicopathological features and patient prognosis and its impact on biological behaviors of HCC cells.

methodsWe examined MPP6 expressions using immunohistochemistry in tumor and adjacent tissues from 118 HCC patients undergoing surgeries in our hospital from January, 2017 to December, 2019, and analyzed the correlation of MPP6 expression levels with clinicopathological data and overall survival (OS) of the patients using Cox regression analysis. In human hepatoma Hep3B cells, the effects of lentivirus-mediated MPP6 knockdown on biological behaviors of the cells were evaluated using colony formation assay, wound-healing assay, Transwell assay and flow cytometry.

resultsCompared with adjacent tissues, HCC tissues showed significant overexpression of MPP6 (

conclusionsMPP6 is highly expressed in HCC tissues and correlates with important clinicopathological features and unfavorable prognosis of the patients. MPP6 knockdown inhibits proliferation, migration and invasion and blocks cell cycle progression in G0/G1 phase.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMembrane ProteinsAntigens, SurfaceCell Line, TumorCell MovementCell ProliferationFemaleHumansMaleMiddle AgedNeoplasm ProteinsPrognosisAntigens, SurfaceMembrane ProteinsNeoplasm ProteinsTM4SF1 protein, humanhepatocellular carcinomamalignant biological behaviorsmembrane protein palmitoylated 6prognosis

Identifiers

PMID41633696
PMCPMC12867608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.