Evidence map›Paper›PMID 41633975›Full record

ReviewCell death & disease2026

Immune checkpoint inhibitor-related pneumonitis: current advances and the putative role of mesenchymal stem cell therapy.

Zekang Li, Xiao Zheng, Han Xia, Long Lu, Xiaodong Chen, Yongjing Chen, Jun Wu, Yufang Shi, Chen Wu

Abstract readReview
In one paragraph

Review in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zekang Li *Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Xiao Zheng *Institute of Cell Therapy, Soochow University, Changzhou, Jiangsu, China.ORCID http://orcid.org/0000-0002-6163-7414
Han XiaDepartment of Oncology, The First People's Hospital of Jingzhou, Jingzhou, Hubei, China.
Long LuDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Xiaodong ChenWuxi Sinotide New Drug Discovery Institutes, Huishan Economic and Technological Development Zone, Wuxi, Jiangsu, China.
Yongjing ChenInstitutes for Translational Medicine, Soochow University, Suzhou, Jiangsu, China.
Jun WuDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Yufang ShiDepartment of Biotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China. yfshi@suda.edu.cn.
Chen WuDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China. chenwucz@163.com.ORCID http://orcid.org/0000-0002-3410-492X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) are widely used in clinical oncology owing to their effectiveness against various tumors. However, by enhancing their immune responses, these inhibitors can trigger immune-related adverse events (irAEs) affecting various organ systems. Notably, pulmonary complications, particularly immune checkpoint inhibitor-related pneumonitis (ICIP), have emerged as one of the leading causes of treatment-related mortality in patients receiving ICIs. Given the limitations of current ICIP treatments, mesenchymal stem cells (MSCs) represent a promising therapeutic strategy owing to their immunomodulatory properties and ability to promote tissue repair. This article reviews recent advances in ICIP and proposes the potential applications of MSC therapy, emphasizing the need for further research into its efficacy and safety to improve ICIP management.

Indexed as

Immune Checkpoint InhibitorsMesenchymal Stem CellsMesenchymal Stem Cell TransplantationPneumoniaAnimalsHumansImmune Checkpoint Inhibitors

Identifiers

PMID41633975
PMCPMC12877017

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.