Evidence map›Paper›PMID 41633980›Full record

Trial reportTranslational psychiatry2026

Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow.

Leo R Silberbauer, Murray B Reed, Gregor Gryglewski, Matej Murgaš, Lukas Nics, Godber Mathis Godbersen, Thomas Stimpfl, Andreas Hahn, Marcus Hacker, Rupert Lanzenberger

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leo R SilberbauerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-8521-1012
Murray B ReedDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Gregor GryglewskiDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-7344-8071
Matej MurgašDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-7643-2182
Lukas NicsDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Godber Mathis GodbersenDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-9739-0724
Thomas StimpflDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-0418-1809
Andreas HahnDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-9727-7580
Marcus HackerDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-4222-4083
Rupert LanzenbergerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. rupert.lanzenberger@meduniwien.ac.at.ORCID http://orcid.org/0000-0003-4641-9539

Funding

Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) 10.55776/DOC33Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) 10.55776/KLI1006Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) 10.55776/KLI504Else Kröner-Fresenius-Stiftung (Else Kroner-Fresenius Foundation) 2014_A192Österreichischen Akademie der Wissenschaften (Austrian Academy of Sciences) DOCVienna Science and Technology Fund (Wiener Wissenschafts-, Forschungs- und Technologiefonds) 10.47379/CS18039
6 · The paper itself

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants, though their mechanisms of action beyond serotonin transporter (SERT) blockade remain unclear [1]. As previous work on BOLD signal changes remain equivocal, pharmacological multimodal neuroimaging of energy demands and blood flow (CBF) holds promise due to increased specificity of these signals. This may advance the understanding of the involved pharmacodynamic mechanisms and guide treatment strategies of highly prevalent neuropsychiatric disorders. We combine new techniques of functional positron emission tomography (fPET) with high temporal resolution (3 seconds) using [

Indexed as

BrainCerebrovascular CirculationCorpus StriatumDorsal Raphe NucleusGlucoseOccipital LobeSelective Serotonin Reuptake InhibitorsAdultDouble-Blind MethodFemaleFluorodeoxyglucose F18HumansMalePositron-Emission TomographyYoung AdultFluorodeoxyglucose F18GlucoseSelective Serotonin Reuptake Inhibitors

Identifiers

PMID41633980
PMCPMC12873367

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.