Evidence map›Paper›PMID 41634017›Full record

ArticleNature communications2026

Gut microbiota-dependent 24-hydroxycholesterol metabolism contributes to capsaicin-induced amelioration of Alzheimer's disease-like pathology in mice.

Yawen Li, Hui Wang, Dongyuan Zhang, Shiqi Wang, Zheng Li, Jingjie Li, Shentao Tai, Dandan Tong, Bifeng Wang, Dingbing Lu and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Yawen Li *Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Hui Wang *Neuroscience Research Institute, Peking University, Beijing, China.
Dongyuan Zhang *Neuroscience Research Institute, Peking University, Beijing, China.
Shiqi Wang *Neuroscience Research Institute, Peking University, Beijing, China.
Zheng LiKey Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
Jingjie LiKey Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.
Shentao TaiDepartment of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Dandan TongDepartment of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Bifeng WangDepartment of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Dingbing LuDepartment of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Shulu YuanNeuroscience Research Institute, Peking University, Beijing, China.
Weiqi SunNeuroscience Research Institute, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-7921-4682
Biyu YangNeuroscience Research Institute, Peking University, Beijing, China.
Chaobo BaiDepartment of Neurology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China.
Qi WangDepartment of Neurology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China.
Jiuyang DingKey Laboratory of Human Brain bank for Functions and Diseases of Department of Education of Guizhou Province, Guizhou Medical University, Guiyang, China.
Zhihao WangDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0002-2517-8679
Yang GaoDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0003-1707-9053
Haitao YuDepartment of Fundamental Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, China.ORCID http://orcid.org/0000-0002-0302-998X
Kun CuiBeijing Life Science Academy, Beijing, China.
Chang LiuBeijing Life Science Academy, Beijing, China.
Jian MaoBeijing Life Science Academy, Beijing, China.
Yun YaoNeuroscience Research Institute, Peking University, Beijing, China.
Fengyu LiuNeuroscience Research Institute, Peking University, Beijing, China.
You WanNeuroscience Research Institute, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-9187-8526
Junliang YuanDepartment of Neurology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China. junliangyuan@bjmu.edu.cn.ORCID http://orcid.org/0009-0004-5030-8350
Xuemei LiuDepartment of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China. onlyoneliuxuemei@163.com.ORCID http://orcid.org/0000-0002-3104-4343
Jie ZhengNeuroscience Research Institute, Peking University, Beijing, China. zhengjiie@hsc.pku.edu.cn.ORCID http://orcid.org/0000-0002-0637-9918

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82160558
6 · The paper itself

Abstract

Dietary capsaicin intake appears to affect the pathogenesis of Alzheimer's disease (AD), while the underlying mechanisms remain unclear. Here, we found in human cohorts that moderate-to-high level of dietary capsaicin intake was associated with improved cognitive performance. Similarly, long-term oral capsaicin administration in male 5×FAD mice ameliorated AD-like pathologies and reshaped gut microbial composition. Gut microbiota transfer from capsaicin-treated mice produced similar effects of capsaicin intake. Moreover, capsaicin elevated the level of host 24(S)-hydroxycholesterol (24-HC), relating to the increase of gut Oscillibacter genus abundance. The 24-HC elevation enhanced microglial phagocytic activity in the brain, and inhibited proinflammatory factors production via liver x receptor β (LXRβ)-mediated transcriptional regulation. Finally, we observed elevation of 24-HC in plasma in AD patients with higher level of dietary capsaicin intake, which correlated with cognitive scores and plasma Aβ and p-tau biomarkers. These findings suggest the potential of capsaicin or capsaicin-rich diets in the prevention or treatment of AD and related diseases.

Indexed as

Alzheimer DiseaseCapsaicinGastrointestinal MicrobiomeHydroxycholesterolsAmyloid beta-PeptidesAnimalsBrainDisease Models, AnimalFemaleHumansLiver X ReceptorsMaleMiceMicroglia24-hydroxycholesterolAmyloid beta-PeptidesCapsaicinHydroxycholesterolsLiver X Receptors

Identifiers

PMID41634017
PMCPMC13013944

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.