Cardiac autonomic function in bronchiectasis and age and gender-matched healthy participants: case-control study.

Dhiya Dinesh, K Vaishali, Anup Bhat, Mukesh Kumar Sinha, Amithash M Prabhudev

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Dhiya DineshDepartment of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

K VaishaliDepartment of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. vaishali.kh@manipal.edu.

Anup BhatDepartment of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Mukesh Kumar SinhaDepartment of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Amithash M PrabhudevDepartment of Respiratory Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to evaluate and compare cardiac autonomic function, specifically through heart rate variability (HRV), between individuals with bronchiectasis and their age- and gender-matched healthy counterparts. This study employed a case-control design, involving 60 participants diagnosed with bronchiectasis (cases) and a control group of healthy individuals matched by age and gender. HRV data was collected over a five-minute interval, focusing on frequency domain parameters including total power, very low frequency (VLF), low frequency (LF), high frequency (HF), and the LF/HF ratio. The bronchiectasis group exhibited a significantly elevated LF/HF ratio, indicating a shift in cardiac sympathovagal balance, relative to the control group (2.25 ± 0.39 vs. 2.05 ± 0.38; p = 0.006). Additionally, marked differences were found in specific frequency domain parameters: LF (2.33 ± 0.55 vs. 2.55 ± 0.46; p = 0.021) and HF (2.06 ± 0.75 vs. 2.5 ± 0.56; p = 0.001). The results suggest a notable disturbance in cardiac autonomic regulation among individuals with bronchiectasis, compared to healthy individuals.

Indexed as

Autonomic Nervous SystemBronchiectasisHeartHeart RateAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedAutonomic modulationAutonomic nervous systemChronic respiratory diseasesHeart rate variabilitySympathetic nervous system

Identifiers

PMID41634076

DOI10.1038/s41598-026-36722-9

PMCPMC12921233

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.