Evidence map›Paper›PMID 41634352›Full record

ArticleScientific reports2026

Biocompatible 3D hierarchical flower-like iron-doped silver nanostructures as a platform for in vitro and in vivo drug delivery.

Wala Almosawy, Amir Landarani-Isfahani, Majid Moghadam, Shahram Tangestaninejad, Iraj Mohammadpoor-Baltork, Maryam Royvaran, Vahideh Asadi, Fatima Koteich, Valiollah Mirkhani

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wala AlmosawyDepartment of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran.
Amir Landarani-IsfahaniDepartment of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran.
Majid MoghadamDepartment of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran. moghadamm@sci.ui.ac.ir.
Shahram TangestaninejadDepartment of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran. stanges@sci.ui.ac.ir.
Iraj Mohammadpoor-BaltorkDepartment of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran.
Maryam RoyvaranKia Nano BioVista Laboratory, Tehran, 14816-34615, Iran.
Vahideh AsadiDepartment of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran.
Fatima KoteichDepartment of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran.
Valiollah MirkhaniDepartment of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanostructured platforms have attracted significant attention as promising drug carriers due to their unique properties and therapeutic efficiency. This work aims to prepare three-dimensional flower-like iron-doped silver nanostructures (HFAg-Fe) and evaluate their potential as nanocarriers for Methotrexate (MTX), a first-generation anticancer and autoimmune drug. The HFAg-Fe were synthesized, modified, and characterized by FE-SEM, FT-IR, XRD, AFM, and elemental analyses. Drug loading and release were studied using UV–vis spectroscopy, showing an MTX loading capacity of 86% and pH-responsive behavior rapid release under acidic tumor conditions and slower release at physiological pH, potentially reducing side effects. Hemolysis and cytotoxicity assays indicated that HFAg-Fe/MTX possessed superior biocompatibility and anticancer efficacy compared to free MTX, while fluorescence microscopy confirmed efficient uptake by cells. Cell cycle analysis showed treatment-induced arrest, mainly at the S phase. X-ray micro-computed Tomography revealed significant tumor volume reduction and preferential accumulation of the nanocarrier at the tumor site. These findings highlight the potential of HFAg-Fe nanostructures as safe drug delivery systems, where 4-aminothiophenol serves as a linker to facilitate drug loading and release, potentially enhancing outcomes in cancer therapy.

Indexed as

Biocompatible MaterialsDrug CarriersDrug Delivery SystemsIronMetal NanoparticlesMethotrexateNanostructuresSilverAnimalsAntineoplastic AgentsCell Line, TumorHemolysisHumansMiceAntineoplastic AgentsBiocompatible MaterialsDrug CarriersIronMethotrexateSilverBiocompatibility studyHierarchical flower-like nanostructuresIron-doped silver nanoparticlesMethotrexate (MTX)pH-responsive drug delivery

Identifiers

PMID41634352
PMCPMC12921315

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.