Evidence map›Paper›PMID 41634377›Full record

ArticleBJC reports2026

Obesity, metformin prescription and risk of advanced prostate cancer in non-diabetic men.

Visalini Nair-Shalliker, Albert Bang, Rani Radhika-Chand, Karen Chiam, Manish I Patel, Anthony M Joshua, Jerry R Greenfield, Michael David, David P Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJC reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Visalini Nair-ShallikerThe Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, Australia. visalini.shalliker@sydney.edu.au.
Albert BangThe Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, Australia.
Rani Radhika-ChandThe Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, Australia.
Karen ChiamThe Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, Australia.
Manish I PatelSpecialty of Surgery, Sydney Medical School, The University of Sydney and Department of Urology, Westmead Hospital, Sydney, NSW, Australia.
Anthony M JoshuaSt. Vincent's Hospital Sydney, Sydney, NSW, Australia.
Jerry R GreenfieldSt Vincent's Healthcare Campus, School of Clinical Medicine, UNSW, Sydney, Australia.
Michael DavidThe Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, Australia.
David P SmithThe Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim is to determine the effects of obesity and metformin-use in predicting prostate cancer (PC) risk.

methodsWe used male participants from the Sax Institute's 45 and Up Study (Australia), recruited between 2005-2009. Participants completed a questionnaire at recruitment which included information on self-reported body mass index (BMI; kg/m

resultsOf the 94,674 eligible participants, there were 5265 incident PC cases (localised n = 2638, regional n = 925, metastatic n = 1514 and unknown; n = 1514) diagnosed between January 2012 and December 2019. BMI ≥ 30 kg/m

conclusionMetformin-use in obese men is associated with reduced PC risk, if detected early. Further research could inform the repurposing of metformin for PC control.

Identifiers

PMID41634377
PMCPMC12867996

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.