Evidence mapPaperPMID 41634702Full record

ReviewCancer cell international2026

The molecular mechanism of IGF2BP3 promoting the malignant progression of lung cancer.

Chenchen Wu, Yufei Ma, Jiafan Li, Bohan Hai, Yueyang Zhou, Fei Cao, Xiaohong Kang, Xuelian Xu

Abstract readReview
In one paragraph

Review in Cancer cell international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chenchen WuDepartment of Radiation Oncology, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, 453100, Henan, China.
Yufei MaLife Science Research Center, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, 453100, Henan, China.
Jiafan LiDepartment of Radiation Oncology, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, 453100, Henan, China.
Bohan HaiDepartment of Rehabilitation, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, 453100, Henan, China.
Yueyang ZhouDepartment of Radiation Oncology, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, 453100, Henan, China.
Fei CaoDepartment of Radiation Oncology, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, 453100, Henan, China.
Xiaohong Kang *Department of Radiation Oncology, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, 453100, Henan, China.
Xuelian Xu *Department of Radiation Oncology, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, 453100, Henan, China. xxl17651951833@163.com.

Funding

Henan Medical Science and Technology Research Program Joint Joint Joint Construction Project LHGJ20220968Henan Provincial Key R & D and Promotion Project (Science and Technology Research) 212102310705National Natural Science Foundation of China 82074231National Natural Science Foundation of China 82074268
6 · The paper itself

Abstract

Lung cancer remains the leading cause of cancer-related mortality worldwide, underscoring the urgent need to elucidate its molecular mechanisms to improve treatment and prognosis. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is aberrantly expressed in lung cancer and is closely associated with malignant progression. As a member of the m6A-modified RNA-binding proteins, IGF2BP3 recognizes and binds to m6A-modified RNAs, thereby regulating RNA stability and translation, ultimately influencing cell proliferation, tumorigenesis, and patient outcomes. This review aims to comprehensively explore the molecular mechanisms by which IGF2BP3 contributes to lung cancer development and progression, and to discuss its potential applications in diagnosis, prognostic assessment, and therapeutic strategies.

Indexed as

Cancer-promoting factorIGF2BP3Lung cancerM6ARNA modification

Identifiers

PMID41634702
PMCPMC12958594

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.