ArticleBMC research notes2026
The association of VEGF-A associated gene polymorphisms with obesity and markers of metabolic syndrome in a black South African population.
Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aim of this study was to determine the association between VEGF-A (rs10434, rs3025040) gene polymorphisms and polymorphisms associated with VEGF-A levels (POLR1C: rs4416670, rs6921438, ZFPM2: rs6993770, rs10738760) with hypertension, adiposity (BMI and waist circumference), diabetes and metabolic syndrome in the black South African population.
resultsNo polymorphisms were associated with VEGF-A levels or metabolic syndrome in our study. The rs6921438 AA genotype was associated with increased BMI (OR: 5.18, 95% CI [1.42; 18.8], p = 0.013) and waist circumference (OR: 3.26, 95% CI [1.21; 8.75], p = 0.019) compared to participants with the rs6921438 G allele. The rs10434 AG genotype was associated with increased BMI (OR: 1.95, 95% CI [1.00; 3.78], p = 0.049), waist circumference (OR: 2.36, 95% CI [1.21; 4.63], p = 0.012) and a lower risk of diabetes (OR: 0.40, 95% CI [0.17; 0.94], p = 0.036) compared to participants with the two homozygous genotypes. Participants with the rs6993770 AT genotype were less likely to have hypertension (OR: 0.46, 95% CI [0.24; 0.91], p = 0.025) compared to participants with the two homozygous genotypes.
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