Evidence map›Paper›PMID 41635019›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2026

Assessing thoughts, feelings and behaviours related to hypoglycaemia: Psychometric evaluation of the Hypoglycaemia Cues Questionnaire (HypoC-Q).

Uffe Søholm, Elizabeth Holmes-Truscott, Stephanie A Amiel, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Rory J McCrimmon, Simon Heller, Mark Evans, Julia K Mader, Pratik Choudhary and 4 more

Abstract read
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Uffe SøholmSchool of Psychology, Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia.
Elizabeth Holmes-TruscottSchool of Psychology, Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia.
Stephanie A AmielDepartment of Diabetes, School of Cardiovascular Medicine and Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID https://orcid.org/0000-0003-2686-5531
Bastiaan de GalanDepartment of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-1255-7741
Ulrik Pedersen-BjergaardDepartment of Endocrinology and Nephrology, Nordsjællands Hospital Hillerød, Hillerød, Denmark.
Rory J McCrimmonSystems Medicine, School of Medicine, University of Dundee, Dundee, UK.ORCID https://orcid.org/0000-0002-3957-1981
Simon HellerUniversity of Sheffield, Sheffield, UK.ORCID https://orcid.org/0000-0002-2425-9565
Mark EvansInstitute of Metabolic Science and Department of Medicine, University of Cambridge, Cambridge, UK.
Julia K MaderDivision of Endocrinology and Diabetology, Department of Internal Medicine Medical University of Graz, Graz, Austria.ORCID https://orcid.org/0000-0001-7854-4233
Pratik ChoudharyDepartment of Diabetes, School of Cardiovascular Medicine and Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID https://orcid.org/0000-0001-7635-4735
Frans PouwerSchool of Psychology, Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia.ORCID https://orcid.org/0000-0002-8172-9818
James A M ShawThe Medical School, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Jane SpeightSchool of Psychology, Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia.ORCID https://orcid.org/0000-0002-1204-6896
Hypo‐RESOLVE Consortium

Funding

Cambridge National Institute for Health Research Biomedical Research Centre.Diabetes UKInnovative Medicines Initiative 2 Joint UndertakingNational Health Service in the East of England through the Clinical Academic ReserveNational Institute for Health ResearchThe Australian Centre for Behavioural Research in Diabetes (ACBRD) - Diabetes Victoria and Deakin University
6 · The paper itself

Abstract

aimsTo describe the design and examine the psychometric properties of the Hypoglycaemia Cues Questionnaire (HypoC-Q) for assessing thoughts, feelings, and behaviours related to hypoglycaemia among adults with type 1 diabetes (T1D).

methodsThe HypoC-Q was designed iteratively, informed by exploratory interviews with 17 adults with T1D with impaired awareness of hypoglycaemia and/or recurrent severe hypoglycaemia, and consultation with diabetologists. Psychometric analyses were completed on baseline data from the Hypo-METRICS study. Data from adults with T1D, reporting at least one hypoglycaemic event, were eligible if they had completed the baseline HypoC-Q. Completion rates, latent structure, internal consistency, construct and known-groups validity were examined.

resultsIn Hypo-METRICS, 154 participants (62% females; mean ± SD age 44 ± 15 years; T1D duration: 23 ± 16 years) were eligible. All completed all 40 HypoC-Q items, demonstrating its acceptability. Exploratory factor analysis identified four scales with satisfactory internal consistency (α = 0.69-0.81): 1) low concern (7 items), 2) burnout (6 items), 3) missing cues (5 items), and 4) delaying treatment (9 items); plus eight items, treated separately. Construct validity was supported by significant moderate correlations between 'burnout' and fear of hypoglycaemia and diabetes distress, and between 'missing' and 'delay' with impaired awareness of hypoglycaemia; all three distinguished between those with intact and impaired awareness (known-groups validity); but not by history of severe hypoglycaemia.

conclusionsThe HypoC-Q is an acceptable, valid, and reliable measure of thoughts, feelings, and behaviours related to hypoglycaemia among adults with T1D. It is available for informing and assessing the effect of interventions to reduce hypoglycaemia exposure and impact.

Indexed as

Diabetes Mellitus, Type 1EmotionsHypoglycemiaAdultCuesFemaleHumansHypoglycemic AgentsMaleMiddle AgedPsychometricsReproducibility of ResultsSurveys and QuestionnairesHypoglycemic Agentsbehaviourscognitionsdiabeteshypoglycaemiaimpaired awarenessPREM

Identifiers

PMID41635019
PMCPMC12982661

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.