Evidence map›Paper›PMID 41635417›Full record

ArticleJournal of medical imaging (Bellingham, Wash.)2026

Airway quantifications of bronchitis patients with photon-counting and energy-integrating computed tomography.

Fong Chi Ho, William Paul Segars, Ehsan Samei, Ehsan Abadi

Abstract read
In one paragraph

Article in Journal of medical imaging (Bellingham, Wash.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fong Chi HoDuke University, Department of Electrical and Computer Engineering, Durham, North Carolina, United States.ORCID https://orcid.org/0000-0002-4152-9037
William Paul SegarsDuke University, Department of Radiology, Durham, North Carolina, United States.
Ehsan SameiDuke University, Department of Radiology, Durham, North Carolina, United States.ORCID https://orcid.org/0000-0001-7451-3309
Ehsan AbadiDuke University, Department of Electrical and Computer Engineering, Durham, North Carolina, United States.ORCID https://orcid.org/0000-0002-9123-5854

Funding

TR&D Project 3: Virtual ReadersP41EB028744 · NIBIB · DUKE UNIVERSITY · PI Ehsan Samei · 2021 to 2026
$7.8M
Simulation Tools for Dynamic CTR01EB001838 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI SAMEI, EHSAN, SEGARS, WILLIAM P · 2005 to 2023
$6.9M
Accuracy and Precision in CT Quantification of COPD Through Virtual Imaging TrialsR01HL155293 · NHLBI · DUKE UNIVERSITY · PI ABADI, EHSAN · 2021 to 2025
$2.2M
NHLBI NIH HHS R01 HL155293NIBIB NIH HHS P41 EB028744NIBIB NIH HHS R01 EB001838
6 · The paper itself

Abstract

Purpose: Accurate airway measurement is critical for bronchitis quantification with computed tomography (CT), yet optimal protocols and the added value of photon-counting CT (PCCT) over energy-integrating CT (EICT) for reducing bias remain unclear. We quantified biomarker accuracy across modalities and protocols and assessed strategies to reduce bias. Approach: A virtual imaging trial with 20 bronchitis anthropomorphic models was scanned using a validated simulator for two systems (EICT: SOMATOM Flash; PCCT: NAEOTOM Alpha) at 6.3 and 12.6 mGy. Reconstructions varied algorithm, kernel sharpness, slice thickness, and pixel size. Pi10 (square-root wall thickness at 10-mm perimeter) and WA% (wall-area percentage) were compared against ground-truth airway dimensions obtained from the 0.1-mm-precision anatomical models prior to CT simulation. External validation used clinical PCCT ( Results: Simulated airway dimensions agreed with pathological references ( Conclusions: PCCT improves the accuracy and consistency of airway biomarker quantification relative to EICT, particularly with optimized protocols. The validated virtual platform enables modality-bias assessment and protocol optimization for accurate, reproducible bronchitis measurements.

Indexed as

chronic obstructive pulmonary diseasecomputational phantomsDukeSimextended cardiac-torsophoton-counting computed tomographyvirtual clinical trial

Identifiers

PMID41635417
PMCPMC12863983

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.