Evidence map›Paper›PMID 41635541›Full record

ArticleFrontiers in endocrinology2025

Neutrophil percentage-to-albumin ratio as a novel hematologic biomarker for predicting arteriogenic erectile dysfunction.

Yangyang Mei, Guoyang Zhang, Yu Liu, Yiming Chen, Renfang Xu, Hao Lu, Hui Gao, Xianchao Sun, Wei Zhang, Xingliang Feng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yangyang MeiDepartment of Urology, Jiangyin People's Hospital, the Jiangyin Clinical College of Xuzhou Medical University, Jiangyin, Jiangsu, China.
Guoyang ZhangDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Yu LiuDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Yiming ChenDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Renfang XuDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Hao LuDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Hui GaoDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xianchao SunDepartment of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Wei ZhangDepartment of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Xingliang FengDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Qianfeng ZhuangDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The neutrophil percentage-to-albumin ratio (NPAR) is a novel composite marker reflecting both inflammatory and nutritional status. However, its association with arteriogenic erectile dysfunction (AED) has not been previously investigated. This study aimed to evaluate the relationship between NPAR and AED and to determine its diagnostic performance compared with conventional hematologic parameters. Methods: A total of 265 men were enrolled from three hospitals between April 2023 and August 2025, including 115 with AED, 53 with venogenic ED (VED), and 97 healthy controls. Erectile function was assessed by the five-item International Index of Erectile Function (IIEF-5), nocturnal penile tumescence and rigidity (NPTR) test and color duplex Doppler ultrasonography (CDDU) was used to classify ED subtypes. Laboratory parameters, including white blood cell (WBC) count, neutrophil percentage (NP), albumin, and NPAR, were measured. Group differences were analyzed using ANOVA or the Kruskal-Wallis test, and independent predictors of AED were identified using multivariate logistic regression. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis. Subgroup analyses were conducted to assess robustness. Results: Compared with controls, individuals with AED exhibited significantly higher WBC levels (5.97 ± 1.13 vs. 5.45 ± 0.90 × 10 Conclusions: Elevated NPAR levels were significantly associated with AED. Compared with WBC and its individual components, NPAR exhibited superior discriminative ability for identifying AED. These findings suggest that NPAR may serve as a convenient and cost-effective hematologic parameter for assessing vascular risk in men with ED, although prospective studies are needed to validate this association.

Indexed as

BiomarkersImpotence, VasculogenicNeutrophilsAdultCase-Control StudiesHumansLeukocyte CountMaleMiddle AgedROC CurveBiomarkersarteriogenic erectile dysfunctionbiomarkerendothelial dysfunctioninflammationneutrophil percentage-to-albumin ratio

Identifiers

PMID41635541
PMCPMC12861870

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.