ArticleBMC plastic and reconstructive surgery2026
Association of cannabis use disorder with postoperative complications following panniculectomy: a multicenter propensity-matched analysis.
Article in BMC plastic and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: As cannabis use continues to rise globally, its impact on surgical outcomes remains poorly characterized. Cannabinoids modulate immune, nociceptive, and vascular pathways, with implications for postoperative healing. This study aimed to evaluate whether cannabis use disorder (CUD) is independently associated with increased complications following infraumbilical panniculectomy. Methods: A retrospective cohort study was conducted using the TriNetX Research Network, a globally federated database of de-identified electronic health records from over 100 healthcare organizations. Adult patients (≥ 18 years old) who underwent infraumbilical panniculectomy between 2010 and 2025 were identified. Patients with CUD documented 6 months preoperatively were propensity score-matched 1:1 to non-users by age, sex, BMI, race or ethnicity, and comorbidities. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for postoperative complications within 90 days. Results: The mean age of the cohort was 43.2 ± 12.3 years, with 80.3% of participants identifying as female. Among 1,596 matched patients (798 CUD, 798 controls), the CUD cohort exhibited significantly higher rates of postprocedural pain (RR 1.82, 95% CI [1.32, 2.46]; Conclusions: Cannabis use disorder is independently associated with increased postoperative pain and wound-related complications following panniculectomy. Surgeons should incorporate cannabis use screening into preoperative risk assessments, particularly in procedures with high soft tissue demand. Limitations include reliance on ICD coding, lack of data on cannabis route or dose, and potential confounding from concurrent nicotine use. Graphical Abstract: Supplementary Information: The online version contains supplementary material available at 10.1186/s44452-026-00013-z.
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