Evidence map›Paper›PMID 41635631›Full record

ArticleObstetrics and gynecology international2026

Pretreatment CRP-Albumin-Lymphocyte (CALLY) Index as a Prognostic Biomarker of Survival and Recurrence-Free Survival in Patients With Early-Stage Cervical Cancer After Radical Hysterectomy: A Multicenter Retrospective Cohort Study.

Mansour Bahardoust, Nasim Ghalavand, Mohammadsadra Shamohammadi, Mina Salehi Asl, Yasaman Tavakoli, Aref Alinejad, Armaghan Abbasi Garavand, Meisam Haghmoradi, Sara Ghorbanzadeh, Adnan Tizmaghz

Abstract read
In one paragraph

Article in Obstetrics and gynecology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mansour BahardoustDepartment of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran, sbmu.ac.ir.ORCID https://orcid.org/0000-0002-0744-2931
Nasim GhalavandSchool of Nursing and Midwifery, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran, ajums.ac.ir.
Mohammadsadra ShamohammadiGastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran, iums.ac.ir.
Mina Salehi AslDepartment of Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, sbmu.ac.ir.
Yasaman TavakoliStudent Research Committee, Department of Medicine, Mazandaran University of Medical Science, Mazandaran, Sari, Iran, mazums.ac.ir.
Aref AlinejadSchool of Medicine, Iran University of Medical Science, Tehran, Iran, iums.ac.ir.
Armaghan Abbasi GaravandStudent Research Committee, Department of Medicine, Mazandaran University of Medical Science, Mazandaran, Sari, Iran, mazums.ac.ir.
Meisam HaghmoradiDepartment of Orthopedic Surgery, Urmia University of Medical Sciences, Urmia, Iran, umsu.ac.ir.
Sara GhorbanzadehDepartment of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran, iums.ac.ir.ORCID https://orcid.org/0009-0004-5825-0325
Adnan TizmaghzDepartment of General Surgery, School of Medicine, Firoozabadi Hospital, Iran University of Medical Sciences, Tehran, Iran, iums.ac.ir.ORCID https://orcid.org/0000-0003-4384-6543

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction/Background: The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a new prognostic biomarker combining CRP, serum albumin, and lymphocyte count that can be associated with the survival of cancer patients by assessing immune, nutritional, and inflammatory status as an important immune indicator. The association of CALLY index as a marker predicting survival of cancer patients with cervical cancer (CC) remains unclear. This study aimed to evaluate the prognostic value of the CALLY index with overall survival (OS) and recurrence-free survival (RFS) in patients with early-stage CC after radical hysterectomy. Methodology: In this multicenter retrospective cohort study, we examined the medical profile of 806 women with early-stage CC who underwent Type II/III radical hysterectomy and bilateral pelvic lymphadenectomy at three centers affiliated to our center between 2012 and 2022. The CALLY index was calculated before treatment. OS and RFS were the primary endpoints. Kaplan-Meier and Cox models assessed the association between CALLY index and outcomes, adjusting for age, histology, tumor size, FIGO stage, grade, extent of lymphadenectomy, and adjuvant therapy. A CALLY index cutoff of 3 maximized discrimination (AUC 0.822; 95% CI, 0.75-0.90). Results: Five-year OS was higher with CALLY index ≥ 3 vs. < 3 (82.1% vs. 71.2%; log rank Conclusions: Pretreatment CALLY index is an independent, readily obtainable prognostic biomarker for OS and RFS after radical hysterectomy in early-stage CC. This index can be useful as a predictor of the prognosis for patients with CC.

Indexed as

CALLYcervical cancerCRP–albumin–lymphocyte indexrecurrencesurvival

Identifiers

PMID41635631
PMCPMC12862499

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.