Evidence map›Paper›PMID 41635797›Full record

ArticleEnvironmental endocrinology (Oxford, England)2026

Polyfluoroalkyl substances and altered glucose homeostasis in adolescents following bariatric surgery.

Elizabeth Costello, Brittney O Baumert, Zhenjiang Li, Vishal Midya, Shudi Pan, Justin R Ryder, Thomas H Inge, Todd M Jenkins, Stephanie Sisley, Stavra A Xanthakos and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental endocrinology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Elizabeth CostelloDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.
Brittney O BaumertDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.
Zhenjiang LiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.
Vishal MidyaDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
Shudi PanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.
Justin R RyderDepartment of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.
Thomas H IngeDepartment of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.
Todd M JenkinsDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, United States.
Stephanie SisleyDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, United States.
Stavra A XanthakosDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, United States.
Anita CourcoulasMinimally Invasive Bariatric and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States.ORCID https://orcid.org/0000-0002-4973-7869
Douglas I WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, 1518 Clifton Road, NE, Atlanta, GA 30322, United States.
Nikos StratakisBarcelona Institute for Global Health, ISGlobal, Dr. Aiguader 88, Barcelona 08003, Spain.
Damaskini ValviDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.ORCID https://orcid.org/0000-0003-4633-229X
Scott M BartellDepartment of Environmental and Occupational Health, Joe C. Wen School of Population & Public Health, University of California, Irvine, Irvine, CA 92697, United States.
Angela L SlittCollege of Pharmacy, The University of Rhode Island, Kingston, RI 02881, United States.ORCID https://orcid.org/0000-0002-0572-7001
Rohit KohliDivision of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA 90027, United States.
Sarah RockDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.
Michele A La MerrillDepartment of Environmental Toxicology, University of California, Davis, CA 95616, United States.
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.
Max T AungDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.
Rob McConnellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.
David V ContiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.
Lida ChatziDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N Soto St., Los Angeles, CA 90032, United States.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KIMBERLY D SIEGMUND · 2016 to 2026
$25.5M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maria Jose Rosa · 2014 to 2026
$21.3M
Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWALP42ES027706 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI Angela L Slitt · 2017 to 2026
$18.9M
Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research ProjectUM1DK072493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI INGE, THOMAS HARRIS · 2011 to 2020
$10.5M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) renewalUM1DK095710 · NIDDK · UNIVERSITY OF CINCINNATI · PI JENKINS, TODD M, XIE, CHANGCHUN · 2011 to 2020
$9.4M
Adolescent Bariatrics: Assessing Health Benefits & RisksU01DK072493 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI INGE, THOMAS HARRIS · 2006 to 2010
$8.7M
Southern California Superfund Research and Training Program for PFAS Assessment, Remediation, and Prevention (ShARP)P42ES036506 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAIA LIDA CHATZI · 2025 to 2026
$8.2M
Untargeted Analysis ResourceU2CES030859 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2019 to 2025
$8.2M
Training Grant in Genomic Analysis and InterpretationT32ES013678 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES, MCCONNELL, ROB S · 2006 to 2023
$5.6M
NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000114NCI NIH HHS P01 CA196569NHGRI NIH HHS U01 HG013288NIDDK NIH HHS R01 DK128117NIDDK NIH HHS U01 DK072493NIDDK NIH HHS UM1 DK072493NIDDK NIH HHS UM1 DK095710NIEHS NIH HHS P2C ES033433NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES023515NIEHS NIH HHS P42 ES027706NIEHS NIH HHS P42 ES036506NIEHS NIH HHS R01 ES030364NIEHS NIH HHS R01 ES030691NIEHS NIH HHS R01 ES032831NIEHS NIH HHS R01 ES033688NIEHS NIH HHS R21 ES035148NIEHS NIH HHS T32 ES013678NIEHS NIH HHS U2C ES030859
6 · The paper itself

Abstract

Objectives: Bariatric surgery is an effective treatment for severe obesity and associated metabolic comorbidities. Exposure to polyfluoroalkyl substance (PFAS) before bariatric surgery may attenuate improvements in glucose metabolism and explain some of the heterogeneity in post-surgery outcomes. Design: This is an observational cohort study. Methods: Adolescents ( Results: Perfluorohexanesulfonic acid (PFHxS) was associated with greater increases in fasting glucose and HbA1c in the 1- to 5-year post-operative period: for instance, a PFHxS level of 1.95 log Conclusions: Perfluorohexanesulfonic acid exposure may attenuate improvement in fasting glucose and HbA1c after bariatric surgery. Improvements in insulin resistance after surgery were not associated with PFAS exposure.

Indexed as

adolescentsbariatric surgeryfasting glucoseHbA1cinsulin resistancePFAS

Identifiers

PMID41635797
PMCPMC12863651

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.