ArticleClinical kidney journal2026
Development and validation of a nomogram for predicting treatment failure in culture-negative peritoneal dialysis-associated peritonitis.
Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Background: Culture-negative peritoneal dialysis-associated peritonitis (CNPDP) carries a high risk of treatment failure but lacks validated prediction tools. This study aimed to develop and validate a clinical nomogram for individualized risk assessment of treatment failure in CNPDP patients. Methods: In this multicenter retrospective study, 288 CNPDP patients treated at Jining Medical University Affiliated Hospital (2013-23) were randomly allocated to training ( Results: LASSO identified five independent predictors: effluent white blood cell count on Day 3 (Eff_WBC_D3), serum albumin (ALB), total cholesterol (TC), magnesium (Mg) and phosphorus (P). The nomogram achieved excellent discrimination: training cohort AUC = 0.897 (95% confidence interval 0.817-0.978), internal validation AUC = 0.861 (0.770-0.952) and external validation AUC = 0.849 (0.750-0.948) with minimal optimism (ΔAUC = 0.036). Eff_WBC_D3 demonstrated the strongest univariate predictive power (AUC = 0.830). Calibration curves showed optimal fit (Hosmer-Lemeshow Conclusion: This externally validated five-variable nomogram, deployed as a freely accessible online tool, offers a robust, practical tool for predicting treatment failure in CNPDP. Its integration of dynamic dialysate markers with routine laboratory data enables personalized early intervention and supports timely clinical decision-making.
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