Evidence map›Paper›PMID 41636071›Full record

ArticleHypertension (Dallas, Tex. : 1979)2026

C-Type Natriuretic Peptide Preserves Vascular and Cardiac Function in Sepsis.

Amie J Moyes, Claire Sand, Leanne Young, Cristina Pérez-Ternero, Aemun T Salam, Reshma S Baliga, Shireen Mohammad, David B Antcliffe, Anthony C Gordon, Aisah A Aubdool and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amie J MoyesFaculty of Medicine and Dentistry, William Harvey Research Institute, Barts & The London Hospitals, Queen Mary University of London, United Kingdom (A.J.M., C.S., L.Y., C.P.-T., A.T.S., R.S.B., S.M., A.A.A., A.J.H.).ORCID 0000-0001-9336-9904
Claire SandFaculty of Medicine and Dentistry, William Harvey Research Institute, Barts & The London Hospitals, Queen Mary University of London, United Kingdom (A.J.M., C.S., L.Y., C.P.-T., A.T.S., R.S.B., S.M., A.A.A., A.J.H.).
Leanne YoungFaculty of Medicine and Dentistry, William Harvey Research Institute, Barts & The London Hospitals, Queen Mary University of London, United Kingdom (A.J.M., C.S., L.Y., C.P.-T., A.T.S., R.S.B., S.M., A.A.A., A.J.H.).
Cristina Pérez-TerneroFaculty of Medicine and Dentistry, William Harvey Research Institute, Barts & The London Hospitals, Queen Mary University of London, United Kingdom (A.J.M., C.S., L.Y., C.P.-T., A.T.S., R.S.B., S.M., A.A.A., A.J.H.).ORCID 0000-0002-2349-0642
Aemun T SalamFaculty of Medicine and Dentistry, William Harvey Research Institute, Barts & The London Hospitals, Queen Mary University of London, United Kingdom (A.J.M., C.S., L.Y., C.P.-T., A.T.S., R.S.B., S.M., A.A.A., A.J.H.).ORCID 0000-0002-8066-8101
Reshma S BaligaFaculty of Medicine and Dentistry, William Harvey Research Institute, Barts & The London Hospitals, Queen Mary University of London, United Kingdom (A.J.M., C.S., L.Y., C.P.-T., A.T.S., R.S.B., S.M., A.A.A., A.J.H.).ORCID 0000-0002-5582-5152
Shireen MohammadFaculty of Medicine and Dentistry, William Harvey Research Institute, Barts & The London Hospitals, Queen Mary University of London, United Kingdom (A.J.M., C.S., L.Y., C.P.-T., A.T.S., R.S.B., S.M., A.A.A., A.J.H.).ORCID 0000-0003-3229-4210
David B AntcliffeFaculty of Medicine, Division of Anesthetics, Pain Medicine and Intensive Care, Imperial College London, United Kingdom (D.B.A., A.C.G.).ORCID 0000-0002-1846-9160
Anthony C GordonFaculty of Medicine, Division of Anesthetics, Pain Medicine and Intensive Care, Imperial College London, United Kingdom (D.B.A., A.C.G.).ORCID 0000-0002-0419-547X
Aisah A AubdoolFaculty of Medicine and Dentistry, William Harvey Research Institute, Barts & The London Hospitals, Queen Mary University of London, United Kingdom (A.J.M., C.S., L.Y., C.P.-T., A.T.S., R.S.B., S.M., A.A.A., A.J.H.).ORCID 0000-0002-4712-9421
Adrian J HobbsFaculty of Medicine and Dentistry, William Harvey Research Institute, Barts & The London Hospitals, Queen Mary University of London, United Kingdom (A.J.M., C.S., L.Y., C.P.-T., A.T.S., R.S.B., S.M., A.A.A., A.J.H.).ORCID 0000-0002-3589-7108

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis is a life-threatening condition and a major cause of mortality in intensive care units worldwide, a clear unmet medical need. CNP (C-type natriuretic peptide) regulates inflammation and cardiovascular homeostasis, but its involvement in sepsis pathogenesis is not fully elucidated. This study investigated the intrinsic role of CNP, and therapeutic potential of the peptide, in offsetting the pathogenesis of sepsis.

methodsPlasma concentrations of CNP, and its N-terminal cleavage product NT-proCNP (N-terminal pro-CNP), were measured in sepsis patients. Cardiac function, vascular hemodynamics, endothelial integrity, and biomarkers of inflammation were analyzed in wild-type, endothelium-restricted (ecCNP

resultsCirculating [NT-proCNP] increased in sepsis patients and was associated with reduced disease severity. ecCNP

conclusionsEndogenous CNP plays a protective role in sepsis by preserving microvascular perfusion, reducing inflammation, maintaining endothelial integrity, and sustaining cardiac function via NPR-C. Pharmacologically targeting CNP signaling warrants further evaluation as a potential therapeutic opportunity in sepsis.

Indexed as

Endothelium, VascularNatriuretic Peptide, C-TypeSepsisAnimalsBiomarkersDisease Models, AnimalHemodynamicsHumansMaleMiceMice, Inbred C57BLMice, KnockoutBiomarkersNatriuretic Peptide, C-Typearterial pressurehypotensionlipopolysaccharidesnatriuretic peptide, C-typesepsis

Identifiers

PMID41636071
PMCPMC13189390

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.