Evidence mapPaperPMID 41636082Full record

ReviewAnnals of neurology2026

Understanding Neurodegenerative Diseases From the -Omics Perspective: Lessons Learnt.

Laura Ibanez, Cyril Pottier, Aleksandra Beric, Daniel Western, Muhammad Ali, Carlos Cruchaga

Registry-linked trialAbstract readReview
In one paragraph

Review in Annals of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07516119 (Assessing Tools That Predict and Stage Mild Cognitive Impairment), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07516119 recruitingnot on this map

Assessing Tools That Predict and Stage Mild Cognitive Impairment

TypeobservationalSponsorPrevention Research Consortium Corp.Ran2026 to 2029Enrolled100ConditionsMild Cognitive Impairment (MCI), Alzheimer Dementia (AD), Alzheimer Disease (AD), APOE-4 Positive
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura IbanezDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-2381-7059
Cyril PottierNeuroGenomics and Informatics Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Aleksandra BericDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Daniel WesternDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Muhammad AliDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Carlos CruchagaDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0276-2899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the population ages, certain neurodegenerative diseases (NDs) are becoming a major health issue. For this reason, this review will focus on the most common ND with onset after 65 years old; Alzheimer's disease, Parkinson's disease, Lewy body dementia, and frontotemporal dementia. NDs are the results of multifactorial processes causing pleiotropic changes in molecular and protein networks linking a host of biological processes that lead to protein dysregulation and aggregation that ultimately leads to neurodegeneration. Genetic, transcriptomic, and proteomic studies have been instrumental to identify novel genes and proteins implicated on diseases that point to novel disease mechanism, as well as the identification of disease biomarkers. Here, we provide a review of the genomic, transcriptomic, and proteomic studies on ND so far, as well as future opportunities and challenges. ANN NEUROL 2026;99:566-587.

Indexed as

GenomicsNeurodegenerative DiseasesProteomicsAlzheimer DiseaseAnimalsHumansMultiomics

Identifiers

PMID41636082
PMCPMC12954156

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.