Evidence map›Paper›PMID 41636637›Full record

ArticleACS sensors2026

Clinical Evaluation of Microneedle Biosensors for Continuous Lactate Monitoring in Critically Ill Patients.

Omeed Djassemi, An-Yi Chang, W Cameron McGuire, Emily Mitchell, Tamoghna Saha, Timothy Fernandes, Jenny Yang, Michael Miller, Cannon Wurster, Sofia Morales-Fermin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS sensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Omeed DjassemiShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, California92093, United States.
An-Yi ChangAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, California92093, United States.
W Cameron McGuireDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, California92093, United States.
Emily MitchellDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, California92093, United States.
Tamoghna SahaAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, California92093, United States.
Timothy FernandesDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, California92093, United States.
Jenny YangDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, California92093, United States.
Michael MillerDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, California92093, United States.
Cannon WursterDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California92092, United States.
Sofia Morales-FerminAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, California92093, United States.
Ian McGregorAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, California92093, United States.
Jose Castillo-ValdovinosShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, California92093, United States.
Atul MalhotraDivision of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California San Diego, La Jolla, California92093, United States.
Joseph WangAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, California92093, United States.

Funding

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
Physiologic Predictors of Respiratory Failure in Patients Presenting with DyspneaF32HL167551 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCGUIRE, WILLIAM CAMERON · 2023 to 2024
$173k
NHLBI NIH HHS F32 HL167551NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

Continuous lactate monitoring is critical for early detection and management of sepsis, shock, and metabolic stress, yet current serum assays remain invasive, intermittent, and resource-intensive. We present a clinical evaluation of a minimally invasive microneedle-based electrochemical biosensor for real-time interstitial fluid (ISF) lactate monitoring. The microneedle biosensor features a platinum working electrode modified with a lactate oxidase reagent layer and a polyvinyl chloride anti-fouling membrane for H

Indexed as

Biosensing TechniquesLactic AcidNeedlesCritical IllnessElectrochemical TechniquesExtracellular FluidFemaleHumansMaleMiddle AgedMixed Function OxygenasesMonitoring, PhysiologicPilot Projectslactate 2-monooxygenaseLactic AcidMixed Function Oxygenasescontinuous lactate monitoringcritical care medicinesepsisshocktranslational medicinewearable microneedle patch

Identifiers

PMID41636637
PMCPMC13278854

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.