Evidence map›Paper›PMID 41636899›Full record

ArticleFish physiology and biochemistry2026

Amelioration of manganese-induced oxidative stress and pathological damage in the intestine of Micropterus salmoides by fermented Chinese herbal.

Zhiwen Yang, Qiuhong Wu, Guang Fan, Pan Zhou, Songsong Bao, Jin Li, Xiaofei Yang, Xinyue Liu, Fangzhou Jing, Li Jiang

Abstract read
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Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhiwen YangCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Qiuhong WuCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Guang FanCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Pan ZhouCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Songsong BaoCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Jin LiCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Xiaofei YangCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Xinyue LiuCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Fangzhou JingCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China.
Li JiangCollege of Life Science and Agriforestry, Southwest University of Science and Technology, Mianyang, Sichuan, China. 1305462380@qq.com.

Funding

China Scholarship Council [202309390007]Entrepreneurship Fund of Southwest University of Science and Technology [24ycx1158]Entrepreneurship Fund of Southwest University of Science and Technology [24ycx1160]
6 · The paper itself

Abstract

This study evaluated the protective effects of fermented Chinese herbal on manganese (Mn)-induced oxidative stress and pathological damage in the intestines of largemouth bass (Micropterus salmoides). The experiment consisted of two treatments: the Mn exposure treatment and the manganese plus fermented Chinese herbal (Mn + FCHM) treatment. In the Mn exposure treatment, fish were exposed to Mn solutions at concentrations of 0, 0.750, 1.125, and 1.688 mg/L, while being fed a basal diet. In the Mn + FCHM treatment, fish were exposed to the same Mn concentrations but were fed a fermented Chinese herbal diet. Each group had three replicates, with 30 fish per replicate, for a duration of 60 days. The results showed that the growth performance of the largemouth bass in the Mn exposure treatment significantly decreased, with structural damage and oxidative stress observed in the intestines (P < 0.05). In the Mn + FCHM treatment, the WGR, SGR, and CF of largemouth bass significantly increased, while VSI and FCR significantly decreased (P < 0.05); The intestinal villi were relatively intact, the Mn deposition in the intestines decreased, and the intestinal damage was significantly improved; The expression levels of intestinal barrier genes Occludin-1, Claudin, and ZO-1 were significantly increased (P < 0.05); The activities of GSH-PX, T-AOC, CAT, and SOD enzymes were significantly enhanced, and the MDA content significantly decreased (P < 0.05); The gene expression levels of GSH-PX, CAT, and SOD were significantly increased (P < 0.05). This study demonstrates that fermented Chinese herbal is effective in mitigating oxidative stress and pathological injuries in the intestines of largemouth bass (Micropterus salmoides) caused by heavy metal manganese (Mn), thereby promoting intestinal health.

Indexed as

BassDrugs, Chinese HerbalIntestinesManganeseOxidative StressAnimalsDietFermentationDrugs, Chinese HerbalManganeseFermented Chinese herbalHeavy metal manganeseIntestinal healthLargemouth bass

Identifiers

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Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.