Observational studyCardiorenal medicine2026
Inclisiran in Chronic Kidney Disease Patients: A Real-World Experience.
Observational study in Cardiorenal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Lipid Disorders in Patients with Renal Failure: Role in Cardiovascular Events and Progression of Chronic Kidney Disease.Life (Basel, Switzerland) · 2026Review
- Inclisiran in advanced chronic kidney disease (stage G4-G5 non-dialysis): sustained LDL-C reduction and favorable safety profile at 1-year follow-up in a real-world case series.Frontiers in medicine · 2026Article
- Lipoprotein(a) and Cardiovascular Risk: Emerging Therapeutic Perspectives with Implications for Chronic Kidney Disease.Cardiorenal medicine · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPatients with chronic kidney disease (CKD) have a high incidence of morbidity and mortality from cardiovascular causes. Among the most significant cardiovascular risk factors is undoubtedly hypercholesterolemia, especially elevated cholesterol LDL levels. The first-line therapy for the management of hypercholesterolemia, including in patients with CKD, is represented by statins even in combination with ezetimibe. In patients with CKD, statin therapy is often poorly tolerated with high incidence of rhabdomyolysis. An alternative treatment is represented by small interfering RNA inclisiran, which has been shown to be effective in double yearly administration.
methodsThirty-two patients (19 males and 13 females) with a mean age of 60.2 years, basal total cholesterol values of 225 mg/dL and LDL cholesterol values of 138 mg/dL were enrolled in our observational study. The mean eGFR value at baseline was 36.93 mL/min/m2. All patients had a diagnosis of chronic ischemic heart disease (CAD), and 4 patients also had type 2 diabetes mellitus. The patients received therapy with inclisiran 284 mg at time zero, then repeated at 3 months and then at 6 months.
resultsAfter 12 months of treatment, there was almost 50% reduction in both total and LDL cholesterol values with no significant change in eGFR values. Only one patient presented with an episode of myocardial infarction 11 months after treatment was started, and no drug-related side effects were reported.
conclusionInclisiran should be considered as a viable therapeutic alternative for the management of pure hypercholesterolemia in patients with CKD who are intolerant to statin treatment because it achieves the optimal LDL cholesterol targets required by actual guidelines without side effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.