Evidence mapPaperPMID 41637494Full record

ArticleScience advances2026

In vivo functional profiling and structural characterization of the human

Liliane El Eid, Yusman Manchanda, Gregory Austin, Kieran Deane-Alder, Roxana-Maria Rujan, Zamara Mariam, Affiong I Oqua, Matthew J Belousoff, Jorge Bernardino de la Serna, Kyle W Sloop and 11 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

21 authors.

Liliane El EidSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-6511-6210
Yusman ManchandaSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-2874-5608
Gregory AustinSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Kieran Deane-AlderDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID 0000-0003-2762-2240
Roxana-Maria RujanCentre for Health and Life Sciences, Coventry University, Coventry, UK.ORCID 0000-0002-4335-3338
Zamara MariamCentre for Health and Life Sciences, Coventry University, Coventry, UK.
Affiong I OquaSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-0584-120X
Matthew J BelousoffDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID 0000-0002-3229-474X
Jorge Bernardino de la SernaNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-1396-3338
Kyle W SloopDiabetes, Obesity and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.ORCID 0000-0001-6748-9929
Guy A RutterSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0001-6360-0343
Alex MontoyaMRC Laboratory of Medical Sciences, London, UK.ORCID 0000-0002-6501-883X
Dominic J WithersMRC Laboratory of Medical Sciences, London, UK.ORCID 0000-0002-8009-7521
Steven J MillershipSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0001-6947-7059
Karim BouzakriCentre Européen d'Étude du Diabète, Strasbourg, France.ORCID 0000-0002-0703-5105
Ben JonesSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0003-0461-2584
Christopher A ReynoldsCentre for Health and Life Sciences, Coventry University, Coventry, UK.ORCID 0000-0001-9267-5141
Patrick M SextonDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID 0000-0001-8902-2473
Denise WoottenDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID 0000-0003-4563-1642
Giuseppe DeganuttiCentre for Health and Life Sciences, Coventry University, Coventry, UK.ORCID 0000-0001-8780-2986
Alejandra TomasSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-2290-8453

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective therapies for type 2 diabetes (T2D) and obesity, yet patient responses are variable, with

Indexed as

Glucagon-Like Peptide-1 ReceptorMutation, MissenseAnimalsBlood GlucoseDiabetes Mellitus, Type 2Glucagon-Like Peptide-1 Receptor AgonistsHumansInsulin-Secreting CellsMaleMiceMolecular Dynamics SimulationProtein ConformationBlood GlucoseGLP1R protein, humanGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor Agonists

Identifiers

PMID41637494
PMCPMC13267291

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.