Evidence map›Paper›PMID 41639447›Full record

ArticleNature2026

Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis.

Haohan K Wei, Chuyue D Yu, Bo Hu, Xing Zeng, Hiroshi Ichise, Liang Li, Yu Wang, Ruiqi L Wang, Ronald N Germain, Rui B Chang and 1 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. The causes of cachexia: key signals and the brain.Nature reviews. Endocrinology · 2026
    Review
  3. The Role of the Nervous System in Lung Disease.Current neurology and neuroscience reports · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. A novel autonomic pathway: implications for vagal-sympathetic reflex physiology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  10. Article
  11. Article
  12. Discovery of a peripherally restricted αCell reports. Medicine · 2026
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haohan K Wei *Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chuyue D Yu *Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3286-3199
Bo HuDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Xing ZengDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2979-7944
Hiroshi IchiseLymphocyte Biology Section, Laboratory of Immune System Biology, NIAID, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5187-810X
Liang LiDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yu WangDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ruiqi L WangDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7176-9560
Ronald N GermainLymphocyte Biology Section, Laboratory of Immune System Biology, NIAID, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1495-9143
Rui B ChangDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA. rui.chang@yale.edu.ORCID 0000-0001-6953-2943
Chengcheng JinDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. chengcheng.jin@pennmedicine.upenn.edu.ORCID 0000-0001-9207-3191

Funding

Understanding the molecular and functional architecture of diverse body-brain pathwaysR01AT012041 · NCCIH · YALE UNIVERSITY · PI CHANG, RUI · 2022 to 2025
$3.0M
Investigating the neutrophil-sensory neuron crosstalk in lung cancerR01CA280601 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Chengcheng Jin · 2023 to 2026
$1.9M
NCCIH NIH HHS R01 AT012041NCI NIH HHS R01 CA280601
6 · The paper itself

Abstract

Body-brain communication has emerged as a key regulator of tissue homeostasis

Indexed as

BrainLung NeoplasmsSensory Receptor CellsSympathetic Nervous SystemAdenocarcinomaAnimalsFemaleHumansMaleMiceReceptors, Adrenergic, beta-2Signal TransductionSingle-Cell AnalysisTumor MicroenvironmentVagus NerveReceptors, Adrenergic, beta-2

Identifiers

PMID41639447
PMCPMC12935554

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.