Evidence map›Paper›PMID 41639581›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2026

Evaluation of the Quality and Suitability of Self-Collected Vaginal and Urine Samples for Human Papillomavirus Testing: A Prospective Matched Study.

Kim Chu, Sofia Vidali, Anna Parberry, Michelle Saull, Krishna Patel, Hannah Mohy-Eldin, Laura White, Adam Brentnall, Peter Sasieni, Rhian Gabe and 3 more

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kim ChuBarts CTU, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0009-0006-0692-1451
Sofia VidaliWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Anna ParberryColposcopy Department, Royal London Hospital, London, UK.
Michelle SaullWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Krishna PatelBarts CTU, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Hannah Mohy-EldinWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Laura WhiteBarts CTU, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Adam BrentnallBarts CTU, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Peter SasieniWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Rhian GabeBarts CTU, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Ranjit ManchandaWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0003-3381-5057
Jack CuzickWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Belinda NedjaiWolfson Institute of Population Health, Queen Mary University of London, London, UK.

Funding

Barts Charity G-002207Cancer Research UK PPRCPJT\100009
6 · The paper itself

Abstract

objectiveTo evaluate the analytical suitability of different storage and laboratory processes of self-samples for an HPV assay.

designProspective matched study.

settingRoyal London Hospital Colposcopy Clinic. POPULATION: One hundred seventy seven patients aged 25-65 years referred to colposcopy due to their screening results (abnormal cytology or recurrent HPV infection).

methodsEach participant provided a first void urine sample (10 mL/20 mL, Collipee), two vaginal self-samples (Copan FLOQSwabs transported 'dry' and 'wet'), and a clinician-collected cervical sample. Samples were processed immediately or after 1 or 2 weeks stored at room temperature. HPV testing used BD Onclarity.

main outcome measuresGenomic DNA Quality Score (GQS), detection of HPV, and HPV cycle threshold (Ct) values.

resultsDNA quality of dry samples was not significantly lower than wet samples when resuspended within 2 weeks (median GQS dry vs. wet: 3.35 vs. 3.41, immediately; 3.00 vs. 3.14, 1 week; 3.45 vs. 2.78, 2 weeks; all p [one-sided] > 0.05). Urine samples had lower HPV positivity compared to other sample types and had higher HPV Ct values (median 30 vs. 27 for dry/wet/clinician samples).

conclusionDry self-samples from a Copan FLOQSwab taken in clinic are likely to have sufficient DNA quality and accuracy for HPV testing compared with wet self-samples and clinician-collected samples if resuspension takes place up to 2 weeks, with storage at room temperature, and using the BD Onclarity assay. Urine samples using the Colli-pee device are likely to be less sensitive for HPV detected from clinician-collected samples.

Indexed as

Human Papillomavirus VirusesPapillomavirus InfectionsSpecimen HandlingUterine Cervical NeoplasmsVaginal SmearsAdultAgedDNA, ViralFemaleHumansMiddle AgedPapillomaviridaeProspective StudiesVaginaDNA, Viralcervical cancerHPVself‐samplingstabilityurinevaginal swab

Identifiers

PMID41639581
PMCPMC13040419

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.