ArticleBMC medical imaging2026
Diffusion kurtosis imaging for detecting renal functional changes in glomerulonephritis: a longitudinal experimental study.
Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundGlomerulonephritis (GN) is a major contributor to chronic kidney disease, highlighting the need for reliable biomarker to monitor GN. This study aimed to evaluate the potential of diffusion kurtosis imaging (DKI) for dynamic assessment of renal injury in GN.
methods90 Sprague-Dawley rats were assigned to control and GN groups. After GN induction, renal DKI was performed at multiple time points (days 2, 5, 10, 15; weeks 4, 6, 10, 14, 16). Longitudinal changes in cortical and outer medullary parameters were assessed, and at each time point GN rats were compared with controls. Correlations with serological biomarkers were analyzed, and histopathology served as reference.
resultsCortical and outer medullary mean diffusivity (MD) progressively decreased, whereas mean kurtosis (MK), axial kurtosis (Ka), and radial kurtosis (Kr) increased. Fractional anisotropy (FA) decreased early and rose at later stages. Outer medullary changes were more pronounced than cortical. At 2 days, only cortical FA was reduced; from 5 days onward, significant alterations appeared in outer medullary MD and Ka as well as cortical and outer medullary FA, followed by widespread changes in all DKI parameters. MD was negatively correlated with renal function markers (r = -0.29 to -0.69), while MK, Ka, and Kr were positively correlated (r = 0.31–0.69); FA showed minimal correlation. ROC analysis demonstrated non-significant diagnostic value for outer medullary FA, whereas other parameters achieved AUCs of 0.688–0.976. Delong analysis identified outer medullary MD as the highest diagnostic accuracy.
conclusionsDKI demonstrates high sensitivity in detecting renal microstructural alterations in GN and shows potential for dynamic monitoring of disease progression.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.