ArticleObesity (Silver Spring, Md.)2026
Mediterranean Versus Western Diet Effects on Obesity Phenotypes and Adipose Tissue Transcriptional Profiles in Female Monkeys.
Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
objectiveObesity, or excessive body fat, is a significant health risk factor. Western diets (WD) contribute to metabolic dysfunction and obesity, while Mediterranean diets (MD) improve metabolic health. This study examined the contrasting effects of WD versus MD on visceral and subcutaneous adipose tissues (VAT, SAT) using a randomized preclinical trial in 38 female cynomolgus macaques assigned to consume either WD (n = 21) or MD (n = 17) for 31 months.
methodsBody composition, metabolic parameters, and adipose transcriptomics were evaluated.
resultsWD significantly induced VAT and SAT accumulation, which was directly associated with insulin resistance, hepatosteatosis, and time spent alone and inversely related to cortisol suppression response to dexamethasone indicating hypothalamic-pituitary glucocorticoid insensitivity. Diet significantly influenced the VAT transcriptome, with MD upregulating pathways linked to RNA processing and protein folding while downregulating those involved in fatty acid oxidation and aerobic respiration.
conclusionsThese findings highlight the protective role of MD against fat accumulation and metabolic dysfunction and provide novel insights into the molecular mechanisms underlying diet-induced obesity. Promoting this dietary pattern may help reduce obesity and chronic disease risk. Further research integrating proteomics and metabolomics is required to better understand diet-induced molecular changes.
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