ArticlePostepy dermatologii i alergologii2025
Microneedling combined with different topically applied medications in treatment of vitiligo patients.
Article in Postepy dermatologii i alergologii, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Introduction: Vitiligo is a chronic skin disorder characterized by melanocyte loss, with treatment aiming to induce repigmentation and maintain disease stability. Microneedling enhances transdermal drug delivery, potentially improving treatment outcomes when combined with topical agents. Aim: This study evaluates and compares the efficacy and safety of microneedling combined with 5-fluorouracil (5-FU), trichloroacetic acid (TCA), and botulinum toxin-A (BTX-A) in vitiligo treatment. Material and methods: This interventional comparative clinical trial included 60 patients with stable non-segmental vitiligo, randomly assigned into three groups: group I (5-FU, Results: Baseline characteristics were comparable across groups ( Conclusions: Microneedling combined with 5-FU showed the highest efficacy, followed by TCA, while BTX-A was the least effective. This approach offers a safe and promising adjunct for vitiligo treatment, achieving faster repigmentation and improving patient adherence.
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