ReviewGenes & diseases2026
The potential clinical implications of extrachromosomal circular DNA as a biomarker.
Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from and are independent of conventional chromosomes. The high specificity and stability of the circular structure of eccDNA provide new clues for its research as a disease biomarker. The recent rapid development of long-read sequencing and eccDNA identification algorithms has greatly expanded our understanding of eccDNA properties. In this review, we introduce the molecular characteristics, biological origin, and advances in detection technology of eccDNA, and mainly summarize the clinical implications of eccDNA in cancer diagnosis and prognosis, drug resistance monitoring, prenatal testing, and immune-related disease, providing support for further exploring new clinical applications of eccDNA.
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